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Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study.

Publication ,  Journal Article
Viala, M; Chiba, A; Thezenas, S; Delmond, L; Lamy, P-J; Mott, SL; Schroeder, MC; Thomas, A; Jacot, W
Published in: BMC Cancer
July 30, 2018

BACKGROUND: There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associated with not attaining a pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) for operable breast cancer. We report the impact of VD on pCR and survival in an expanded cohort. METHODS: Patients from Iowa and Montpellier registries who had serum VD level measured before or during NAC were included. Vitamin D deficiency was defined as < 20 ng/mL. Pathological complete response was defined as no residual invasive disease in the breast and lymph nodes. Survival was defined from the date of diagnosis to the date of relapse (PFS) or date of death (OS). RESULTS: The study included 327 women. Vitamin D deficiency was associated with the odds of not attaining pCR (p = 0.04). Fifty-four patients relapsed and 52 patients died. In multivariate analysis, stage III disease, triple-negative (TN) subtype and the inability to achieve pCR were independently associated with inferior survival. Vitamin D deficiency was not significantly associated with survival in the overall sample; however a trend was seen in the TN (5-years PFS 60.4% vs. 72.3%, p = 0.3), and in the hormone receptor positive /human epidermal growth factor receptor 2 negative (HER2-) subgroups (5-years PFS 89% vs 78%, p = 0.056). CONCLUSION: Vitamin D deficiency is associated with the inability to reach pCR in breast cancer patients undergoing NAC.

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Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

July 30, 2018

Volume

18

Issue

1

Start / End Page

770

Location

England

Related Subject Headings

  • Vitamin D
  • Retrospective Studies
  • Recurrence
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • 4202 Epidemiology
 

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Viala, M., Chiba, A., Thezenas, S., Delmond, L., Lamy, P.-J., Mott, S. L., … Jacot, W. (2018). Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study. BMC Cancer, 18(1), 770. https://doi.org/10.1186/s12885-018-4686-x
Viala, Marie, Akiko Chiba, Simon Thezenas, Laure Delmond, Pierre-Jean Lamy, Sarah L. Mott, Mary C. Schroeder, Alexandra Thomas, and William Jacot. “Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study.BMC Cancer 18, no. 1 (July 30, 2018): 770. https://doi.org/10.1186/s12885-018-4686-x.
Viala M, Chiba A, Thezenas S, Delmond L, Lamy P-J, Mott SL, et al. Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study. BMC Cancer. 2018 Jul 30;18(1):770.
Viala, Marie, et al. “Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study.BMC Cancer, vol. 18, no. 1, July 2018, p. 770. Pubmed, doi:10.1186/s12885-018-4686-x.
Viala M, Chiba A, Thezenas S, Delmond L, Lamy P-J, Mott SL, Schroeder MC, Thomas A, Jacot W. Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study. BMC Cancer. 2018 Jul 30;18(1):770.
Journal cover image

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

July 30, 2018

Volume

18

Issue

1

Start / End Page

770

Location

England

Related Subject Headings

  • Vitamin D
  • Retrospective Studies
  • Recurrence
  • Oncology & Carcinogenesis
  • Neoadjuvant Therapy
  • Middle Aged
  • Humans
  • Female
  • Breast Neoplasms
  • 4202 Epidemiology