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Stacking the DEK: from chromatin topology to cancer stem cells.

Publication ,  Journal Article
Privette Vinnedge, LM; Kappes, F; Nassar, N; Wells, SI
Published in: Cell cycle (Georgetown, Tex.)
January 2013

Stem cells are essential for development and tissue maintenance and display molecular markers and functions distinct from those of differentiated cell types in a given tissue. Malignant cells that exhibit stem cell-like activities have been detected in many types of cancers and have been implicated in cancer recurrence and drug resistance. Normal stem cells and cancer stem cells have striking commonalities, including shared cell surface markers and signal transduction pathways responsible for regulating quiescence vs. proliferation, self-renewal, pluripotency and differentiation. As the search continues for markers that distinguish between stem cells, progenitor cells and cancer stem cells, growing evidence suggests that a unique chromatin-associated protein called DEK may confer stem cell-like qualities. Here, we briefly describe current knowledge regarding stem and progenitor cells. We then focus on new findings that implicate DEK as a regulator of stem and progenitor cell qualities, potentially through its unusual functions in the regulation of local or global chromatin organization.

Duke Scholars

Published In

Cell cycle (Georgetown, Tex.)

DOI

EISSN

1551-4005

ISSN

1538-4101

Publication Date

January 2013

Volume

12

Issue

1

Start / End Page

51 / 66

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Poly-ADP-Ribose Binding Proteins
  • Oncogene Proteins
  • Neoplastic Stem Cells
  • Humans
  • Developmental Biology
  • DNA Repair
  • Chromosomal Proteins, Non-Histone
  • Chromatin
  • 3101 Biochemistry and cell biology
 

Citation

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Privette Vinnedge, L. M., Kappes, F., Nassar, N., & Wells, S. I. (2013). Stacking the DEK: from chromatin topology to cancer stem cells. Cell Cycle (Georgetown, Tex.), 12(1), 51–66. https://doi.org/10.4161/cc.23121
Privette Vinnedge, Lisa M., Ferdinand Kappes, Nicolas Nassar, and Susanne I. Wells. “Stacking the DEK: from chromatin topology to cancer stem cells.Cell Cycle (Georgetown, Tex.) 12, no. 1 (January 2013): 51–66. https://doi.org/10.4161/cc.23121.
Privette Vinnedge LM, Kappes F, Nassar N, Wells SI. Stacking the DEK: from chromatin topology to cancer stem cells. Cell cycle (Georgetown, Tex). 2013 Jan;12(1):51–66.
Privette Vinnedge, Lisa M., et al. “Stacking the DEK: from chromatin topology to cancer stem cells.Cell Cycle (Georgetown, Tex.), vol. 12, no. 1, Jan. 2013, pp. 51–66. Epmc, doi:10.4161/cc.23121.
Privette Vinnedge LM, Kappes F, Nassar N, Wells SI. Stacking the DEK: from chromatin topology to cancer stem cells. Cell cycle (Georgetown, Tex). 2013 Jan;12(1):51–66.

Published In

Cell cycle (Georgetown, Tex.)

DOI

EISSN

1551-4005

ISSN

1538-4101

Publication Date

January 2013

Volume

12

Issue

1

Start / End Page

51 / 66

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Poly-ADP-Ribose Binding Proteins
  • Oncogene Proteins
  • Neoplastic Stem Cells
  • Humans
  • Developmental Biology
  • DNA Repair
  • Chromosomal Proteins, Non-Histone
  • Chromatin
  • 3101 Biochemistry and cell biology