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ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty.

Publication ,  Journal Article
Rodriguez-Mañas, L; Araujo de Carvalho, I; Bhasin, S; Bischoff-Ferrari, HA; Cesari, M; Evans, W; Hare, JM; Pahor, M; Parini, A; Rolland, Y ...
Published in: J Frailty Aging
2020

Biomarkers of frailty and sarcopenia are essential to advance the understanding of these conditions of aging and develop new diagnostic tools and effective treatments. The International Conference on Frailty and Sarcopenia Research (ICFSR) Task Force - a group of academic and industry scientists from around the world -- met in February 2019 to discuss the current state of biomarker development for frailty and sarcopenia. The D3Cr dilution method, which assesses creatinine excretion as a biochemical measure of muscle mass, was suggested as a more accurate measure of functional muscle mass than assessment by dual energy x-ray absorptiometry (DXA). Proposed biomarkers of frailty include markers of inflammation, the hypothalamic-pituitary-adrenal (HPA) axis response to stress, altered glucose insulin dynamics, endocrine dysregulation, aging, and others, acknowledging the complex multisystem etiology that contributes to frailty. Lack of clarity regarding a regulatory pathway for biomarker development has hindered progress; however, there are currently several international efforts to develop such biomarkers as tools to improve the treatment of individuals presenting these conditions.

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Published In

J Frailty Aging

DOI

ISSN

2260-1341

Publication Date

2020

Volume

9

Issue

1

Start / End Page

4 / 8

Location

France

Related Subject Headings

  • Sarcopenia
  • Humans
  • Frailty
  • Congresses as Topic
  • Biomarkers
  • Advisory Committees
  • 1608 Sociology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rodriguez-Mañas, L., Araujo de Carvalho, I., Bhasin, S., Bischoff-Ferrari, H. A., Cesari, M., Evans, W., … Vellas, B. (2020). ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty. J Frailty Aging, 9(1), 4–8. https://doi.org/10.14283/jfa.2019.32
Rodriguez-Mañas, L., I. Araujo de Carvalho, S. Bhasin, H. A. Bischoff-Ferrari, M. Cesari, W. Evans, J. M. Hare, et al. “ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty.J Frailty Aging 9, no. 1 (2020): 4–8. https://doi.org/10.14283/jfa.2019.32.
Rodriguez-Mañas L, Araujo de Carvalho I, Bhasin S, Bischoff-Ferrari HA, Cesari M, Evans W, et al. ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty. J Frailty Aging. 2020;9(1):4–8.
Rodriguez-Mañas, L., et al. “ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty.J Frailty Aging, vol. 9, no. 1, 2020, pp. 4–8. Pubmed, doi:10.14283/jfa.2019.32.
Rodriguez-Mañas L, Araujo de Carvalho I, Bhasin S, Bischoff-Ferrari HA, Cesari M, Evans W, Hare JM, Pahor M, Parini A, Rolland Y, Fielding RA, Walston J, Vellas B. ICFSR Task Force Perspective on Biomarkers for Sarcopenia and Frailty. J Frailty Aging. 2020;9(1):4–8.

Published In

J Frailty Aging

DOI

ISSN

2260-1341

Publication Date

2020

Volume

9

Issue

1

Start / End Page

4 / 8

Location

France

Related Subject Headings

  • Sarcopenia
  • Humans
  • Frailty
  • Congresses as Topic
  • Biomarkers
  • Advisory Committees
  • 1608 Sociology
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences