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Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome.

Publication ,  Journal Article
Toescu, SM; Bruckert, L; Jabarkheel, R; Yecies, D; Zhang, M; Clark, CA; Mankad, K; Aquilina, K; Grant, GA; Feldman, HM; Travis, KE; Yeom, KW
Published in: Neuroimage Clin
2022

Cerebellar mutism syndrome, characterised by mutism, emotional lability and cerebellar motor signs, occurs in up to 39% of children following resection of medulloblastoma, the most common malignant posterior fossa tumour of childhood. Its pathophysiology remains unclear, but prior studies have implicated damage to the superior cerebellar peduncles. In this study, the objective was to conduct high-resolution spatial profilometry of the cerebellar peduncles and identify anatomic biomarkers of cerebellar mutism syndrome. In this retrospective study, twenty-eight children with medulloblastoma (mean age 8.8 ± 3.8 years) underwent diffusion MRI at four timepoints over one year. Forty-nine healthy children (9.0 ± 4.2 years), scanned at a single timepoint, served as age- and sex-matched controls. Automated Fibre Quantification was used to segment cerebellar peduncles and compute fractional anisotropy (FA) at 30 nodes along each tract. Thirteen patients developed cerebellar mutism syndrome. FA was significantly lower in the distal third of the left superior cerebellar peduncle pre-operatively in all patients compared to controls (FA in proximal third 0.228, middle and distal thirds 0.270, p = 0.01, Cohen's d = 0.927). Pre-operative differences in FA did not predict cerebellar mutism syndrome. However, post-operative reductions in FA were highly specific to the distal left superior cerebellar peduncle, and were most pronounced in children with cerebellar mutism syndrome compared to those without at the 1-4 month follow up (0.325 vs 0.512, p = 0.042, d = 1.36) and at the 1-year follow up (0.342, vs 0.484, p = 0.038, d = 1.12). High spatial resolution cerebellar profilometry indicated a site-specific alteration of the distal segment of the superior cerebellar peduncle seen in cerebellar mutism syndrome which may have important surgical implications in the treatment of these devastating tumours of childhood.

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Published In

Neuroimage Clin

DOI

EISSN

2213-1582

Publication Date

2022

Volume

35

Start / End Page

103000

Location

Netherlands

Related Subject Headings

  • Syndrome
  • Retrospective Studies
  • Mutism
  • Medulloblastoma
  • Humans
  • Child, Preschool
  • Child
  • Cerebellum
  • Cerebellar Neoplasms
  • Cerebellar Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Toescu, S. M., Bruckert, L., Jabarkheel, R., Yecies, D., Zhang, M., Clark, C. A., … Yeom, K. W. (2022). Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome. Neuroimage Clin, 35, 103000. https://doi.org/10.1016/j.nicl.2022.103000
Toescu, Sebastian M., Lisa Bruckert, Rashad Jabarkheel, Derek Yecies, Michael Zhang, Christopher A. Clark, Kshitij Mankad, et al. “Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome.Neuroimage Clin 35 (2022): 103000. https://doi.org/10.1016/j.nicl.2022.103000.
Toescu SM, Bruckert L, Jabarkheel R, Yecies D, Zhang M, Clark CA, et al. Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome. Neuroimage Clin. 2022;35:103000.
Toescu, Sebastian M., et al. “Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome.Neuroimage Clin, vol. 35, 2022, p. 103000. Pubmed, doi:10.1016/j.nicl.2022.103000.
Toescu SM, Bruckert L, Jabarkheel R, Yecies D, Zhang M, Clark CA, Mankad K, Aquilina K, Grant GA, Feldman HM, Travis KE, Yeom KW. Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome. Neuroimage Clin. 2022;35:103000.

Published In

Neuroimage Clin

DOI

EISSN

2213-1582

Publication Date

2022

Volume

35

Start / End Page

103000

Location

Netherlands

Related Subject Headings

  • Syndrome
  • Retrospective Studies
  • Mutism
  • Medulloblastoma
  • Humans
  • Child, Preschool
  • Child
  • Cerebellum
  • Cerebellar Neoplasms
  • Cerebellar Diseases