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Age-dependent Intracranial Artery Morphology in Healthy Children.

Publication ,  Journal Article
Quon, JL; Mouches, P; Kim, LH; Jabarkheel, R; Zhang, Y; Steinberg, GK; Grant, GA; Edwards, MSB; Yeom, KW; Forkert, ND
Published in: Clin Neuroradiol
March 2022

PURPOSE: Evaluation of intracranial artery morphology plays an important role in diagnosing a variety of neurovascular diseases. In addition to clinical symptoms, diagnosis currently relies on qualitative rather than quantitative evaluation of vascular imaging sequences, such as magnetic resonance angiography (MRA). However, there is a paucity of literature on normal arterial morphology in the pediatric population across brain development. We aimed to quantitatively assess normal, age-related changes in artery morphology in children. METHODS: We performed retrospective analysis of pediatric MRA data obtained from a tertiary referral center. An MRA dataset from 98 children (49 boys/49 girls) aged 0.6-20 years (median = 11.5 years) with normal intracranial vasculature was retrospectively collected between 2011 and 2018. All arteries were automatically segmented to determine the vessel radius. Using an atlas-based approach, the average radius and density of arteries were measured in the three main cerebral vascular territories and the radius of five major arteries was determined at corresponding locations. RESULTS: The radii of the major arteries as well as the average artery radius and density in the different vascular territories in the brain remained constant throughout childhood and adolescence (|r| < 0.369 in all cases). CONCLUSION: This study presents the first automated evaluation of intracranial vessel morphology on MRA across childhood. Our results can serve as a framework for quantitative evaluation of cerebral vessel morphology in the setting of pediatric neurovascular diseases.

Duke Scholars

Published In

Clin Neuroradiol

DOI

EISSN

1869-1447

Publication Date

March 2022

Volume

32

Issue

1

Start / End Page

49 / 56

Location

Germany

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Male
  • Magnetic Resonance Angiography
  • Infant
  • Humans
  • Female
  • Child, Preschool
  • Child
  • Cerebral Arteries
 

Citation

APA
Chicago
ICMJE
MLA
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Quon, J. L., Mouches, P., Kim, L. H., Jabarkheel, R., Zhang, Y., Steinberg, G. K., … Forkert, N. D. (2022). Age-dependent Intracranial Artery Morphology in Healthy Children. Clin Neuroradiol, 32(1), 49–56. https://doi.org/10.1007/s00062-021-01071-9
Quon, Jennifer L., Pauline Mouches, Lily H. Kim, Rashad Jabarkheel, Yi Zhang, Gary K. Steinberg, Gerald A. Grant, Michael S. B. Edwards, Kristen W. Yeom, and Nils D. Forkert. “Age-dependent Intracranial Artery Morphology in Healthy Children.Clin Neuroradiol 32, no. 1 (March 2022): 49–56. https://doi.org/10.1007/s00062-021-01071-9.
Quon JL, Mouches P, Kim LH, Jabarkheel R, Zhang Y, Steinberg GK, et al. Age-dependent Intracranial Artery Morphology in Healthy Children. Clin Neuroradiol. 2022 Mar;32(1):49–56.
Quon, Jennifer L., et al. “Age-dependent Intracranial Artery Morphology in Healthy Children.Clin Neuroradiol, vol. 32, no. 1, Mar. 2022, pp. 49–56. Pubmed, doi:10.1007/s00062-021-01071-9.
Quon JL, Mouches P, Kim LH, Jabarkheel R, Zhang Y, Steinberg GK, Grant GA, Edwards MSB, Yeom KW, Forkert ND. Age-dependent Intracranial Artery Morphology in Healthy Children. Clin Neuroradiol. 2022 Mar;32(1):49–56.
Journal cover image

Published In

Clin Neuroradiol

DOI

EISSN

1869-1447

Publication Date

March 2022

Volume

32

Issue

1

Start / End Page

49 / 56

Location

Germany

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Male
  • Magnetic Resonance Angiography
  • Infant
  • Humans
  • Female
  • Child, Preschool
  • Child
  • Cerebral Arteries