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Toward a Comprehensive Delineation of White Matter Tract-Related Deformation.

Publication ,  Journal Article
Zhou, Z; Li, X; Liu, Y; Fahlstedt, M; Georgiadis, M; Zhan, X; Raymond, SJ; Grant, G; Kleiven, S; Camarillo, D; Zeineh, M
Published in: J Neurotrauma
December 2021

Finite element (FE) models of the human head are valuable instruments to explore the mechanobiological pathway from external loading, localized brain response, and resultant injury risks. The injury predictability of these models depends on the use of effective criteria as injury predictors. The FE-derived normal deformation along white matter (WM) fiber tracts (i.e., tract-oriented strain) recently has been suggested as an appropriate predictor for axonal injury. However, the tract-oriented strain only represents a partial depiction of the WM fiber tract deformation. A comprehensive delineation of tract-related deformation may improve the injury predictability of the FE head model by delivering new tract-related criteria as injury predictors. Thus, the present study performed a theoretical strain analysis to comprehensively characterize the WM fiber tract deformation by relating the strain tensor of the WM element to its embedded fiber tract. Three new tract-related strains with exact analytical solutions were proposed, measuring the normal deformation perpendicular to the fiber tracts (i.e., tract-perpendicular strain), and shear deformation along and perpendicular to the fiber tracts (i.e., axial-shear strain and lateral-shear strain, respectively). The injury predictability of these three newly proposed strain peaks along with the previously used tract-oriented strain peak and maximum principal strain (MPS) were evaluated by simulating 151 impacts with known outcome (concussion or non-concussion). The results preliminarily showed that four tract-related strain peaks exhibited superior performance than MPS in discriminating concussion and non-concussion cases. This study presents a comprehensive quantification of WM tract-related deformation and advocates the use of orientation-dependent strains as criteria for injury prediction, which may ultimately contribute to an advanced mechanobiological understanding and enhanced computational predictability of brain injury.

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Published In

J Neurotrauma

DOI

EISSN

1557-9042

Publication Date

December 2021

Volume

38

Issue

23

Start / End Page

3260 / 3278

Location

United States

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Nerve Fibers, Myelinated
  • Models, Theoretical
  • Humans
  • Diffuse Axonal Injury
  • Brain Injuries, Traumatic
  • Brain Concussion
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhou, Z., Li, X., Liu, Y., Fahlstedt, M., Georgiadis, M., Zhan, X., … Zeineh, M. (2021). Toward a Comprehensive Delineation of White Matter Tract-Related Deformation. J Neurotrauma, 38(23), 3260–3278. https://doi.org/10.1089/neu.2021.0195
Zhou, Zhou, Xiaogai Li, Yuzhe Liu, Madelen Fahlstedt, Marios Georgiadis, Xianghao Zhan, Samuel J. Raymond, et al. “Toward a Comprehensive Delineation of White Matter Tract-Related Deformation.J Neurotrauma 38, no. 23 (December 2021): 3260–78. https://doi.org/10.1089/neu.2021.0195.
Zhou Z, Li X, Liu Y, Fahlstedt M, Georgiadis M, Zhan X, et al. Toward a Comprehensive Delineation of White Matter Tract-Related Deformation. J Neurotrauma. 2021 Dec;38(23):3260–78.
Zhou, Zhou, et al. “Toward a Comprehensive Delineation of White Matter Tract-Related Deformation.J Neurotrauma, vol. 38, no. 23, Dec. 2021, pp. 3260–78. Pubmed, doi:10.1089/neu.2021.0195.
Zhou Z, Li X, Liu Y, Fahlstedt M, Georgiadis M, Zhan X, Raymond SJ, Grant G, Kleiven S, Camarillo D, Zeineh M. Toward a Comprehensive Delineation of White Matter Tract-Related Deformation. J Neurotrauma. 2021 Dec;38(23):3260–3278.
Journal cover image

Published In

J Neurotrauma

DOI

EISSN

1557-9042

Publication Date

December 2021

Volume

38

Issue

23

Start / End Page

3260 / 3278

Location

United States

Related Subject Headings

  • White Matter
  • Neurology & Neurosurgery
  • Nerve Fibers, Myelinated
  • Models, Theoretical
  • Humans
  • Diffuse Axonal Injury
  • Brain Injuries, Traumatic
  • Brain Concussion
  • 1109 Neurosciences
  • 1103 Clinical Sciences