Skip to main content
Journal cover image

The relationship between brain injury criteria and brain strain across different types of head impacts can be different.

Publication ,  Journal Article
Zhan, X; Li, Y; Liu, Y; Domel, AG; Alizadeh, HV; Raymond, SJ; Ruan, J; Barbat, S; Tiernan, S; Gevaert, O; Zeineh, MM; Grant, GA; Camarillo, DB
Published in: J R Soc Interface
June 2021

Multiple brain injury criteria (BIC) are developed to quickly quantify brain injury risks after head impacts. These BIC originated from different head impact types (e.g. sports and car crashes) are widely used in risk evaluation. However, the accuracy of using the BIC on brain injury risk estimation across head impact types has not been evaluated. Physiologically, brain strain is often considered the key parameter of brain injury. To evaluate the BIC's risk estimation accuracy across five datasets comprising different head impact types, linear regression was used to model 95% maximum principal strain, 95% maximum principal strain at the corpus callosum and cumulative strain damage (15%) on 18 BIC. The results show significantly different relationships between BIC and brain strain across datasets, indicating the same BIC value may suggest different brain strain across head impact types. The accuracy of brain strain regression is generally decreasing if the BIC regression models are fitted on a dataset with a different type of head impact rather than on the dataset with the same type. Given this finding, this study raises concerns for applying BIC to estimate the brain injury risks for head impacts different from the head impacts on which the BIC was developed.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J R Soc Interface

DOI

EISSN

1742-5662

Publication Date

June 2021

Volume

18

Issue

179

Start / End Page

20210260

Location

England

Related Subject Headings

  • Linear Models
  • Humans
  • Head
  • General Science & Technology
  • Finite Element Analysis
  • Brain Injuries
  • Brain
  • Biomechanical Phenomena
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhan, X., Li, Y., Liu, Y., Domel, A. G., Alizadeh, H. V., Raymond, S. J., … Camarillo, D. B. (2021). The relationship between brain injury criteria and brain strain across different types of head impacts can be different. J R Soc Interface, 18(179), 20210260. https://doi.org/10.1098/rsif.2021.0260
Zhan, Xianghao, Yiheng Li, Yuzhe Liu, August G. Domel, Hossein Vahid Alizadeh, Samuel J. Raymond, Jesse Ruan, et al. “The relationship between brain injury criteria and brain strain across different types of head impacts can be different.J R Soc Interface 18, no. 179 (June 2021): 20210260. https://doi.org/10.1098/rsif.2021.0260.
Zhan X, Li Y, Liu Y, Domel AG, Alizadeh HV, Raymond SJ, et al. The relationship between brain injury criteria and brain strain across different types of head impacts can be different. J R Soc Interface. 2021 Jun;18(179):20210260.
Zhan, Xianghao, et al. “The relationship between brain injury criteria and brain strain across different types of head impacts can be different.J R Soc Interface, vol. 18, no. 179, June 2021, p. 20210260. Pubmed, doi:10.1098/rsif.2021.0260.
Zhan X, Li Y, Liu Y, Domel AG, Alizadeh HV, Raymond SJ, Ruan J, Barbat S, Tiernan S, Gevaert O, Zeineh MM, Grant GA, Camarillo DB. The relationship between brain injury criteria and brain strain across different types of head impacts can be different. J R Soc Interface. 2021 Jun;18(179):20210260.
Journal cover image

Published In

J R Soc Interface

DOI

EISSN

1742-5662

Publication Date

June 2021

Volume

18

Issue

179

Start / End Page

20210260

Location

England

Related Subject Headings

  • Linear Models
  • Humans
  • Head
  • General Science & Technology
  • Finite Element Analysis
  • Brain Injuries
  • Brain
  • Biomechanical Phenomena