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Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets.

Publication ,  Journal Article
Prince, E; Whelan, R; Donson, A; Staulcup, S; Hengartner, A; Vijmasi, T; Agwu, C; Lillehei, KO; Foreman, NK; Johnston, JM; Massimi, L; Ginn, K ...
Published in: Acta Neuropathol Commun
May 13, 2020

Adamantinomatous craniopharyngioma (ACP) is a biologically benign but clinically aggressive lesion that has a significant impact on quality of life. The incidence of the disease has a bimodal distribution, with peaks occurring in children and older adults. Our group previously published the results of a transcriptome analysis of pediatric ACPs that identified several genes that were consistently overexpressed relative to other pediatric brain tumors and normal tissue. We now present the results of a transcriptome analysis comparing pediatric to adult ACP to identify biological differences between these groups that may provide novel therapeutic insights or support the assertion that potential therapies identified through the study of pediatric ACP may also have a role in adult ACP. Using our compiled transcriptome dataset of 27 pediatric and 9 adult ACPs, obtained through the Advancing Treatment for Pediatric Craniopharyngioma Consortium, we interrogated potential age-related transcriptional differences using several rigorous mathematical analyses. These included: canonical differential expression analysis; divisive, agglomerative, and probabilistic based hierarchical clustering; information theory based characterizations; and the deep learning approach, HD Spot. Our work indicates that there is no therapeutically relevant difference in ACP gene expression based on age. As such, potential therapeutic targets identified in pediatric ACP are also likely to have relvance for adult patients.

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Published In

Acta Neuropathol Commun

DOI

EISSN

2051-5960

Publication Date

May 13, 2020

Volume

8

Issue

1

Start / End Page

68

Location

England

Related Subject Headings

  • Transcriptome
  • Pituitary Neoplasms
  • Middle Aged
  • Humans
  • Gene Expression Profiling
  • Craniopharyngioma
  • Computational Biology
  • Child
  • Adult
  • 3209 Neurosciences
 

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Prince, E., Whelan, R., Donson, A., Staulcup, S., Hengartner, A., Vijmasi, T., … Advancing Treatment for Pediatric Craniopharyngioma Consortium, . (2020). Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets. Acta Neuropathol Commun, 8(1), 68. https://doi.org/10.1186/s40478-020-00939-0
Prince, Eric, Ros Whelan, Andrew Donson, Susan Staulcup, Astrid Hengartner, Trinka Vijmasi, Chibueze Agwu, et al. “Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets.Acta Neuropathol Commun 8, no. 1 (May 13, 2020): 68. https://doi.org/10.1186/s40478-020-00939-0.
Prince E, Whelan R, Donson A, Staulcup S, Hengartner A, Vijmasi T, et al. Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets. Acta Neuropathol Commun. 2020 May 13;8(1):68.
Prince, Eric, et al. “Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets.Acta Neuropathol Commun, vol. 8, no. 1, May 2020, p. 68. Pubmed, doi:10.1186/s40478-020-00939-0.
Prince E, Whelan R, Donson A, Staulcup S, Hengartner A, Vijmasi T, Agwu C, Lillehei KO, Foreman NK, Johnston JM, Massimi L, Anderson RCE, Souweidane MM, Naftel RP, Limbrick DD, Grant G, Niazi TN, Dudley R, Kilburn L, Jackson EM, Jallo GI, Ginn K, Smith A, Chern JJ, Lee A, Drapeau A, Krieger MD, Handler MH, Hankinson TC, Advancing Treatment for Pediatric Craniopharyngioma Consortium. Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets. Acta Neuropathol Commun. 2020 May 13;8(1):68.
Journal cover image

Published In

Acta Neuropathol Commun

DOI

EISSN

2051-5960

Publication Date

May 13, 2020

Volume

8

Issue

1

Start / End Page

68

Location

England

Related Subject Headings

  • Transcriptome
  • Pituitary Neoplasms
  • Middle Aged
  • Humans
  • Gene Expression Profiling
  • Craniopharyngioma
  • Computational Biology
  • Child
  • Adult
  • 3209 Neurosciences