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Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.

Publication ,  Journal Article
McAllister, TW; Zafonte, R; Jain, S; Flashman, LA; George, MS; Grant, GA; He, F; Lohr, JB; Andaluz, N; Summerall, L; Paulus, MP; Raman, R; Stein, MB
Published in: Neuropsychopharmacology
April 2016

We report findings from a 12-week randomized double-blinded placebo-controlled trial of methylphenidate or galantamine to treat emotional and cognitive complaints in individuals (n=32) with a history of PTSD, TBI, or both conditions. In this small pilot study, methylphenidate treatment was associated with clinically meaningful and statistically significant improvement compared with placebo on the primary outcome, a measure of cognitive complaints (Ruff Neurobehavioral Inventory-Postmorbid Cognitive Scale), as well as on the secondary outcomes reflecting post-concussive (Rivermead Post Concussive Symptom Questionnaire) and post-traumatic stress symptoms (Posttraumatic Stress Disorder Checklist). Treatment was well tolerated. These results suggest the need for a larger RCT to replicate and confirm these findings. Design considerations for such a trial should include the need for multiple sites to facilitate adequate recruitment and extension of the treatment and follow-up periods.

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Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

April 2016

Volume

41

Issue

5

Start / End Page

1191 / 1198

Location

England

Related Subject Headings

  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Pilot Projects
  • Neuropsychological Tests
  • Middle Aged
  • Methylphenidate
  • Male
  • Humans
  • Galantamine
 

Citation

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McAllister, T. W., Zafonte, R., Jain, S., Flashman, L. A., George, M. S., Grant, G. A., … Stein, M. B. (2016). Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury. Neuropsychopharmacology, 41(5), 1191–1198. https://doi.org/10.1038/npp.2015.282
McAllister, Thomas W., Ross Zafonte, Sonia Jain, Laura A. Flashman, Mark S. George, Gerald A. Grant, Feng He, et al. “Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.Neuropsychopharmacology 41, no. 5 (April 2016): 1191–98. https://doi.org/10.1038/npp.2015.282.
McAllister TW, Zafonte R, Jain S, Flashman LA, George MS, Grant GA, et al. Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury. Neuropsychopharmacology. 2016 Apr;41(5):1191–8.
McAllister, Thomas W., et al. “Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury.Neuropsychopharmacology, vol. 41, no. 5, Apr. 2016, pp. 1191–98. Pubmed, doi:10.1038/npp.2015.282.
McAllister TW, Zafonte R, Jain S, Flashman LA, George MS, Grant GA, He F, Lohr JB, Andaluz N, Summerall L, Paulus MP, Raman R, Stein MB. Randomized Placebo-Controlled Trial of Methylphenidate or Galantamine for Persistent Emotional and Cognitive Symptoms Associated with PTSD and/or Traumatic Brain Injury. Neuropsychopharmacology. 2016 Apr;41(5):1191–1198.

Published In

Neuropsychopharmacology

DOI

EISSN

1740-634X

Publication Date

April 2016

Volume

41

Issue

5

Start / End Page

1191 / 1198

Location

England

Related Subject Headings

  • Treatment Outcome
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Pilot Projects
  • Neuropsychological Tests
  • Middle Aged
  • Methylphenidate
  • Male
  • Humans
  • Galantamine