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Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.

Publication ,  Journal Article
Hübel, C; Gaspar, HA; Coleman, JRI; Hanscombe, KB; Purves, K; Prokopenko, I; Graff, M; Ngwa, JS; Workalemahu, T; O'Reilly, PF; Bulik, CM ...
Published in: Nat Commun
December 18, 2019

Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

December 18, 2019

Volume

10

Issue

1

Start / End Page

5765

Location

England

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Physical Fitness
  • Phenotype
  • Overweight
  • Multifactorial Inheritance
  • Middle Aged
  • Mental Disorders
  • Male
  • Humans
 

Citation

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Hübel, C., Gaspar, H. A., Coleman, J. R. I., Hanscombe, K. B., Purves, K., Prokopenko, I., … Breen, G. (2019). Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. Nat Commun, 10(1), 5765. https://doi.org/10.1038/s41467-019-13544-0
Hübel, Christopher, Héléna A. Gaspar, Jonathan R. I. Coleman, Ken B. Hanscombe, Kirstin Purves, Inga Prokopenko, Mariaelisa Graff, et al. “Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.Nat Commun 10, no. 1 (December 18, 2019): 5765. https://doi.org/10.1038/s41467-019-13544-0.
Hübel C, Gaspar HA, Coleman JRI, Hanscombe KB, Purves K, Prokopenko I, et al. Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. Nat Commun. 2019 Dec 18;10(1):5765.
Hübel, Christopher, et al. “Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent.Nat Commun, vol. 10, no. 1, Dec. 2019, p. 5765. Pubmed, doi:10.1038/s41467-019-13544-0.
Hübel C, Gaspar HA, Coleman JRI, Hanscombe KB, Purves K, Prokopenko I, Graff M, Ngwa JS, Workalemahu T, ADHD Working Group of the Psychiatric Genomics Consortium, Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC), Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, PTSD Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, International Headache Genetics Consortium, O’Reilly PF, Bulik CM, Breen G. Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. Nat Commun. 2019 Dec 18;10(1):5765.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

December 18, 2019

Volume

10

Issue

1

Start / End Page

5765

Location

England

Related Subject Headings

  • Sex Factors
  • Risk Factors
  • Physical Fitness
  • Phenotype
  • Overweight
  • Multifactorial Inheritance
  • Middle Aged
  • Mental Disorders
  • Male
  • Humans