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GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.

Publication ,  Journal Article
Pasman, JA; Verweij, KJH; Gerring, Z; Stringer, S; Sanchez-Roige, S; Treur, JL; Abdellaoui, A; Nivard, MG; Baselmans, BML; Ong, J-S; Ip, HF ...
Published in: Nat Neurosci
September 2018

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independent single nucleotide polymorphisms in six regions. All measured genetic variants combined explained 11% of the variance. Gene-based tests revealed 35 significant genes in 16 regions, and S-PrediXcan analyses showed that 21 genes had different expression levels for cannabis users versus nonusers. The strongest finding across the different analyses was CADM2, which has been associated with substance use and risk-taking. Significant genetic correlations were found with 14 of 25 tested substance use and mental health-related traits, including smoking, alcohol use, schizophrenia and risk-taking. Mendelian randomization analysis showed evidence for a causal positive influence of schizophrenia risk on cannabis use. Overall, our study provides new insights into the etiology of cannabis use and its relation with mental health.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

September 2018

Volume

21

Issue

9

Start / End Page

1161 / 1170

Location

United States

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Risk-Taking
  • Polymorphism, Single Nucleotide
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Health
  • Mendelian Randomization Analysis
  • Marijuana Abuse
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pasman, J. A., Verweij, K. J. H., Gerring, Z., Stringer, S., Sanchez-Roige, S., Treur, J. L., … Vink, J. M. (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci, 21(9), 1161–1170. https://doi.org/10.1038/s41593-018-0206-1
Pasman, Joëlle A., Karin J. H. Verweij, Zachary Gerring, Sven Stringer, Sandra Sanchez-Roige, Jorien L. Treur, Abdel Abdellaoui, et al. “GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.Nat Neurosci 21, no. 9 (September 2018): 1161–70. https://doi.org/10.1038/s41593-018-0206-1.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, et al. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 Sep;21(9):1161–70.
Pasman, Joëlle A., et al. “GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.Nat Neurosci, vol. 21, no. 9, Sept. 2018, pp. 1161–70. Pubmed, doi:10.1038/s41593-018-0206-1.
Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong J-S, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL, 23andMe Research Team, de Wit H, Davis LK, MacKillop J, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM. GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nat Neurosci. 2018 Sep;21(9):1161–1170.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

September 2018

Volume

21

Issue

9

Start / End Page

1161 / 1170

Location

United States

Related Subject Headings

  • Young Adult
  • Schizophrenia
  • Risk-Taking
  • Polymorphism, Single Nucleotide
  • Neurology & Neurosurgery
  • Middle Aged
  • Mental Health
  • Mendelian Randomization Analysis
  • Marijuana Abuse
  • Male