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Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.

Publication ,  Journal Article
Chatterjee, P; Ponnapati, M; Kramme, C; Plesa, AM; Church, GM; Jacobson, JM
Published in: Communications biology
November 2020

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has elicited a global health crisis of catastrophic proportions. With only a few vaccines approved for early or limited use, there is a critical need for effective antiviral strategies. In this study, we report a unique antiviral platform, through computational design of ACE2-derived peptides which both target the viral spike protein receptor binding domain (RBD) and recruit E3 ubiquitin ligases for subsequent intracellular degradation of SARS-CoV-2 in the proteasome. Our engineered peptide fusions demonstrate robust RBD degradation capabilities in human cells and are capable of inhibiting infection-competent viral production, thus prompting their further experimental characterization and therapeutic development.

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Published In

Communications biology

DOI

EISSN

2399-3642

ISSN

2399-3642

Publication Date

November 2020

Volume

3

Issue

1

Start / End Page

715

Related Subject Headings

  • Virus Attachment
  • Ubiquitin-Protein Ligases
  • Spike Glycoprotein, Coronavirus
  • SARS-CoV-2
  • Ribonucleoproteins
  • Recombinant Fusion Proteins
  • Receptors, Virus
  • Proteolysis
  • Protein Engineering
  • Protein Domains
 

Citation

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Chatterjee, P., Ponnapati, M., Kramme, C., Plesa, A. M., Church, G. M., & Jacobson, J. M. (2020). Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Communications Biology, 3(1), 715. https://doi.org/10.1038/s42003-020-01470-7
Chatterjee, Pranam, Manvitha Ponnapati, Christian Kramme, Alexandru M. Plesa, George M. Church, and Joseph M. Jacobson. “Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.Communications Biology 3, no. 1 (November 2020): 715. https://doi.org/10.1038/s42003-020-01470-7.
Chatterjee P, Ponnapati M, Kramme C, Plesa AM, Church GM, Jacobson JM. Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Communications biology. 2020 Nov;3(1):715.
Chatterjee, Pranam, et al. “Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.Communications Biology, vol. 3, no. 1, Nov. 2020, p. 715. Epmc, doi:10.1038/s42003-020-01470-7.
Chatterjee P, Ponnapati M, Kramme C, Plesa AM, Church GM, Jacobson JM. Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions. Communications biology. 2020 Nov;3(1):715.

Published In

Communications biology

DOI

EISSN

2399-3642

ISSN

2399-3642

Publication Date

November 2020

Volume

3

Issue

1

Start / End Page

715

Related Subject Headings

  • Virus Attachment
  • Ubiquitin-Protein Ligases
  • Spike Glycoprotein, Coronavirus
  • SARS-CoV-2
  • Ribonucleoproteins
  • Recombinant Fusion Proteins
  • Receptors, Virus
  • Proteolysis
  • Protein Engineering
  • Protein Domains