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Selection against admixture and gene regulatory divergence in a long-term primate field study.

Publication ,  Journal Article
Vilgalys, TP; Fogel, AS; Anderson, JA; Mututua, RS; Warutere, JK; Siodi, IL; Kim, SY; Voyles, TN; Robinson, JA; Wall, JD; Archie, EA; Tung, J ...
Published in: Science (New York, N.Y.)
August 2022

Genetic admixture is central to primate evolution. We combined 50 years of field observations of immigration and group demography with genomic data from ~9 generations of hybrid baboons to investigate the consequences of admixture in the wild. Despite no obvious fitness costs to hybrids, we found signatures of selection against admixture similar to those described for archaic hominins. These patterns were concentrated near genes where ancestry is strongly associated with gene expression. Our analyses also show that introgression is partially predictable across the genome. This study demonstrates the value of integrating genomic and field data for revealing how "genomic signatures of selection" (e.g., reduced introgression in low-recombination regions) manifest in nature; moreover, it underscores the importance of other primates as living models for human evolution.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 2022

Volume

377

Issue

6606

Start / End Page

635 / 641

Related Subject Headings

  • Selection, Genetic
  • Papio
  • Hybridization, Genetic
  • Genome
  • General Science & Technology
  • Animals
 

Citation

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Vilgalys, T. P., Fogel, A. S., Anderson, J. A., Mututua, R. S., Warutere, J. K., Siodi, I. L., … Tung, J. (2022). Selection against admixture and gene regulatory divergence in a long-term primate field study. Science (New York, N.Y.), 377(6606), 635–641. https://doi.org/10.1126/science.abm4917
Vilgalys, Tauras P., Arielle S. Fogel, Jordan A. Anderson, Raphael S. Mututua, J Kinyua Warutere, I Long’ida Siodi, Sang Yoon Kim, et al. “Selection against admixture and gene regulatory divergence in a long-term primate field study.Science (New York, N.Y.) 377, no. 6606 (August 2022): 635–41. https://doi.org/10.1126/science.abm4917.
Vilgalys TP, Fogel AS, Anderson JA, Mututua RS, Warutere JK, Siodi IL, et al. Selection against admixture and gene regulatory divergence in a long-term primate field study. Science (New York, NY). 2022 Aug;377(6606):635–41.
Vilgalys, Tauras P., et al. “Selection against admixture and gene regulatory divergence in a long-term primate field study.Science (New York, N.Y.), vol. 377, no. 6606, Aug. 2022, pp. 635–41. Epmc, doi:10.1126/science.abm4917.
Vilgalys TP, Fogel AS, Anderson JA, Mututua RS, Warutere JK, Siodi IL, Kim SY, Voyles TN, Robinson JA, Wall JD, Archie EA, Alberts SC, Tung J. Selection against admixture and gene regulatory divergence in a long-term primate field study. Science (New York, NY). 2022 Aug;377(6606):635–641.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

August 2022

Volume

377

Issue

6606

Start / End Page

635 / 641

Related Subject Headings

  • Selection, Genetic
  • Papio
  • Hybridization, Genetic
  • Genome
  • General Science & Technology
  • Animals