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Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.

Publication ,  Journal Article
Tcheandjieu, C; Zhu, X; Hilliard, AT; Clarke, SL; Napolioni, V; Ma, S; Lee, KM; Fang, H; Chen, F; Lu, Y; Tsao, NL; Raghavan, S; Koyama, S ...
Published in: Nat Med
August 2022

We report a genome-wide association study (GWAS) of coronary artery disease (CAD) incorporating nearly a quarter of a million cases, in which existing studies are integrated with data from cohorts of white, Black and Hispanic individuals from the Million Veteran Program. We document near equivalent heritability of CAD across multiple ancestral groups, identify 95 novel loci, including nine on the X chromosome, detect eight loci of genome-wide significance in Black and Hispanic individuals, and demonstrate that two common haplotypes at the 9p21 locus are responsible for risk stratification in all populations except those of African origin, in which these haplotypes are virtually absent. Moreover, in the largest GWAS for angiographically derived coronary atherosclerosis performed to date, we find 15 loci of genome-wide significance that robustly overlap with established loci for clinical CAD. Phenome-wide association analyses of novel loci and polygenic risk scores (PRSs) augment signals related to insulin resistance, extend pleiotropic associations of these loci to include smoking and family history, and precisely document the markedly reduced transferability of existing PRSs to Black individuals. Downstream integrative analyses reinforce the critical roles of vascular endothelial, fibroblast, and smooth muscle cells in CAD susceptibility, but also point to a shared biology between atherosclerosis and oncogenesis. This study highlights the value of diverse populations in further characterizing the genetic architecture of CAD.

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Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

August 2022

Volume

28

Issue

8

Start / End Page

1679 / 1692

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Immunology
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Coronary Artery Disease
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tcheandjieu, C., Zhu, X., Hilliard, A. T., Clarke, S. L., Napolioni, V., Ma, S., … Assimes, T. L. (2022). Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med, 28(8), 1679–1692. https://doi.org/10.1038/s41591-022-01891-3
Tcheandjieu, Catherine, Xiang Zhu, Austin T. Hilliard, Shoa L. Clarke, Valerio Napolioni, Shining Ma, Kyung Min Lee, et al. “Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.Nat Med 28, no. 8 (August 2022): 1679–92. https://doi.org/10.1038/s41591-022-01891-3.
Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, et al. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med. 2022 Aug;28(8):1679–92.
Tcheandjieu, Catherine, et al. “Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.Nat Med, vol. 28, no. 8, Aug. 2022, pp. 1679–92. Pubmed, doi:10.1038/s41591-022-01891-3.
Tcheandjieu C, Zhu X, Hilliard AT, Clarke SL, Napolioni V, Ma S, Lee KM, Fang H, Chen F, Lu Y, Tsao NL, Raghavan S, Koyama S, Gorman BR, Vujkovic M, Klarin D, Levin MG, Sinnott-Armstrong N, Wojcik GL, Plomondon ME, Maddox TM, Waldo SW, Bick AG, Pyarajan S, Huang J, Song R, Ho Y-L, Buyske S, Kooperberg C, Haessler J, Loos RJF, Do R, Verbanck M, Chaudhary K, North KE, Avery CL, Graff M, Haiman CA, Le Marchand L, Wilkens LR, Bis JC, Leonard H, Shen B, Lange LA, Giri A, Dikilitas O, Kullo IJ, Stanaway IB, Jarvik GP, Gordon AS, Hebbring S, Namjou B, Kaufman KM, Ito K, Ishigaki K, Kamatani Y, Verma SS, Ritchie MD, Kember RL, Baras A, Lotta LA, Regeneron Genetics Center, CARDIoGRAMplusC4D Consortium, Biobank Japan, Million Veteran Program, Kathiresan S, Hauser ER, Miller DR, Lee JS, Saleheen D, Reaven PD, Cho K, Gaziano JM, Natarajan P, Huffman JE, Voight BF, Rader DJ, Chang K-M, Lynch JA, Damrauer SM, Wilson PWF, Tang H, Sun YV, Tsao PS, O’Donnell CJ, Assimes TL. Large-scale genome-wide association study of coronary artery disease in genetically diverse populations. Nat Med. 2022 Aug;28(8):1679–1692.

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

August 2022

Volume

28

Issue

8

Start / End Page

1679 / 1692

Location

United States

Related Subject Headings

  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Immunology
  • Humans
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Coronary Artery Disease
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences