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Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405.

Publication ,  Journal Article
Van Blarigan, EL; Ma, C; Ou, F-S; Bainter, TM; Venook, AP; Ng, K; Niedzwiecki, D; Giovannucci, E; Lenz, H-J; Polite, BN; Hochster, HS ...
Published in: Int J Cancer
January 15, 2023

Data on diet and survival among people with metastatic colorectal cancer are limited. We examined dietary fat in relation to all-cause mortality and cancer progression or death among 1149 people in the Cancer and Leukemia Group B (Alliance)/Southwest Oncology Group (SWOG) 80405 trial who completed a food frequency questionnaire at initiation of treatment for advanced or metastatic colorectal cancer. We examined saturated, monounsaturated, total and specific types (n-3, long-chain n-3 and n-6) of polyunsaturated fat, animal and vegetable fats. We hypothesized higher vegetable fat intake would be associated with lower risk of all-cause mortality and cancer progression. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI). Over median follow-up of 6.1 years (interquartile range [IQR]: 5.3, 7.2 y), we observed 974 deaths and 1077 events of progression or death. Participants had a median age of 59 y; 41% were female and 86% identified as White. Moderate or higher vegetable fat was associated with lower risk of mortality and cancer progression or death (HRs comparing second, third and fourth to first quartile for all-cause mortality: 0.74 [0.62, 0.90]; 0.75 [0.61, 0.91]; 0.79 [0.63, 1.00]; P trend: .12; for cancer progression or death: 0.74 [0.62, 0.89]; 0.78 [0.64, 0.95]; 0.71 [0.57, 0.88]; P trend: .01). No other fat type was associated with all-cause mortality and cancer progression or death. Moderate or higher vegetable fat intake may be associated with lower risk of cancer progression or death among people with metastatic colorectal cancer.

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

January 15, 2023

Volume

152

Issue

2

Start / End Page

123 / 136

Location

United States

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Male
  • Female
  • Dietary Fats
  • Diet
  • Colonic Neoplasms
  • Cause of Death
  • Cardiovascular Diseases
  • Animals
 

Citation

APA
Chicago
ICMJE
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Van Blarigan, E. L., Ma, C., Ou, F.-S., Bainter, T. M., Venook, A. P., Ng, K., … Meyerhardt, J. A. (2023). Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405. Int J Cancer, 152(2), 123–136. https://doi.org/10.1002/ijc.34230
Van Blarigan, Erin L., Chao Ma, Fang-Shu Ou, Tiffany M. Bainter, Alan P. Venook, Kimmie Ng, Donna Niedzwiecki, et al. “Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405.Int J Cancer 152, no. 2 (January 15, 2023): 123–36. https://doi.org/10.1002/ijc.34230.
Van Blarigan, Erin L., et al. “Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405.Int J Cancer, vol. 152, no. 2, Jan. 2023, pp. 123–36. Pubmed, doi:10.1002/ijc.34230.
Van Blarigan EL, Ma C, Ou F-S, Bainter TM, Venook AP, Ng K, Niedzwiecki D, Giovannucci E, Lenz H-J, Polite BN, Hochster HS, Goldberg RM, Mayer RJ, Blanke CD, O’Reilly EM, Ciombor KK, Meyerhardt JA. Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405. Int J Cancer. 2023 Jan 15;152(2):123–136.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

January 15, 2023

Volume

152

Issue

2

Start / End Page

123 / 136

Location

United States

Related Subject Headings

  • Rectal Neoplasms
  • Oncology & Carcinogenesis
  • Male
  • Female
  • Dietary Fats
  • Diet
  • Colonic Neoplasms
  • Cause of Death
  • Cardiovascular Diseases
  • Animals