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Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently.

Publication ,  Journal Article
Rubenstein, D; Sweitzer, MM; Scroggs, LB; Denlinger-Apte, RL; Kozink, R; McClernon, FJ
Published in: Drug Alcohol Depend
September 1, 2022

BACKGROUND: Half of young adults who smoke use menthol cigarettes, which is associated with continued smoking and greater nicotine dependence. Additionally, early subjective reactions to cigarettes predict future use. Menthol may blunt the sensory effects of nicotine. We investigated the moderating role of menthol on subjective reactions to, and choice of varied nicotine content cigarettes in young adults who smoke infrequently. METHODS: In three counterbalanced, double-blinded sessions, young adults who smoke ≤ 15 days/month smoked fixed doses from very low (VLNC), intermediate (INC), and normal (NNC) nicotine content cigarettes, which were menthol or non-menthol depending on preference. Participants chose their preferred cigarette in a final session. Positive and negative subjective reactions were measured in each session. ANOVA tests investigated the relationship between menthol preference, nicotine content, and subjective reactions. RESULTS: Participants (N = 87) were 18-25 years old and reported smoking 15.2 cigarettes per month over 8 days (35 % menthol). Non-menthol preferring participants had increased negative reactions with greater nicotine content (F(1, 55)= 10.76, p < .001); menthol preferring participants did not. Choice of higher nicotine cigarettes was associated with having reported a greater difference in positive reactions to NNC and VLNC for non-menthol preferring participants (F(1, 55)= 12.72, p < .001) but not for menthol preferring participants. CONCLUSIONS: Young adults who smoke infrequently are a priority tobacco control population given their high risk of transitioning to daily smoking. Results from this study in the form of subjective reactions indicate that a menthol ban is required for a nicotine reduction standard to be maximally effective in this vulnerable group.

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Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

September 1, 2022

Volume

238

Start / End Page

109580

Location

Ireland

Related Subject Headings

  • Young Adult
  • Tobacco Use Disorder
  • Tobacco Products
  • Substance Abuse
  • Smoking
  • Nicotine
  • Menthol
  • Humans
  • Adult
  • Adolescent
 

Citation

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Rubenstein, D., Sweitzer, M. M., Scroggs, L. B., Denlinger-Apte, R. L., Kozink, R., & McClernon, F. J. (2022). Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently. Drug Alcohol Depend, 238, 109580. https://doi.org/10.1016/j.drugalcdep.2022.109580
Rubenstein, Dana, Maggie M. Sweitzer, Lauren B. Scroggs, Rachel L. Denlinger-Apte, Rachel Kozink, and F Joseph McClernon. “Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently.Drug Alcohol Depend 238 (September 1, 2022): 109580. https://doi.org/10.1016/j.drugalcdep.2022.109580.
Rubenstein D, Sweitzer MM, Scroggs LB, Denlinger-Apte RL, Kozink R, McClernon FJ. Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently. Drug Alcohol Depend. 2022 Sep 1;238:109580.
Rubenstein, Dana, et al. “Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently.Drug Alcohol Depend, vol. 238, Sept. 2022, p. 109580. Pubmed, doi:10.1016/j.drugalcdep.2022.109580.
Rubenstein D, Sweitzer MM, Scroggs LB, Denlinger-Apte RL, Kozink R, McClernon FJ. Menthol preference moderates the relationship between cigarette nicotine content choice and reactions in young adults who smoke infrequently. Drug Alcohol Depend. 2022 Sep 1;238:109580.
Journal cover image

Published In

Drug Alcohol Depend

DOI

EISSN

1879-0046

Publication Date

September 1, 2022

Volume

238

Start / End Page

109580

Location

Ireland

Related Subject Headings

  • Young Adult
  • Tobacco Use Disorder
  • Tobacco Products
  • Substance Abuse
  • Smoking
  • Nicotine
  • Menthol
  • Humans
  • Adult
  • Adolescent