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Multiaxial fields improve SABRE efficiency by preserving hydride order.

Publication ,  Journal Article
Eriksson, SL; Mammen, MW; Eriksson, CW; Lindale, JR; Warren, WS
Published in: Journal of magnetic resonance (San Diego, Calif. : 1997)
August 5, 2022

Signal Amplification By Reversible Exchange (SABRE) and the heteronuclear variant, X-SABRE, increase the sensitivity of magnetic resonance techniques using order derived from reversible binding of para-hydrogen. One current limitation of SABRE is suboptimal polarization transfer over the lifetime of the complex. Here, we demonstrate a multiaxial low-field pulse sequence which allows optimal polarization build-up during a low-field "evolution" pulse, followed by a high-field "mixing" pulse which permits proton decoupling along an orthogonal axis. This preserves the singlet character of the hydrides while allowing exchange to replenish the ligands on the iridium catalyst. This strategy leads to a 2.5-fold improvement over continuous field SABRE SHEATH experimentally which was confirmed with numerical simulation.

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Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

August 5, 2022

Volume

342

Start / End Page

107282

Related Subject Headings

  • Protons
  • Magnetic Resonance Spectroscopy
  • Iridium
  • Hydrogen
  • Catalysis
  • Biophysics
  • 51 Physical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences
 

Citation

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Eriksson, S. L., Mammen, M. W., Eriksson, C. W., Lindale, J. R., & Warren, W. S. (2022). Multiaxial fields improve SABRE efficiency by preserving hydride order. Journal of Magnetic Resonance (San Diego, Calif. : 1997), 342, 107282. https://doi.org/10.1016/j.jmr.2022.107282
Eriksson, Shannon L., Mathew W. Mammen, Clark W. Eriksson, Jacob R. Lindale, and Warren S. Warren. “Multiaxial fields improve SABRE efficiency by preserving hydride order.Journal of Magnetic Resonance (San Diego, Calif. : 1997) 342 (August 5, 2022): 107282. https://doi.org/10.1016/j.jmr.2022.107282.
Eriksson SL, Mammen MW, Eriksson CW, Lindale JR, Warren WS. Multiaxial fields improve SABRE efficiency by preserving hydride order. Journal of magnetic resonance (San Diego, Calif : 1997). 2022 Aug 5;342:107282.
Eriksson, Shannon L., et al. “Multiaxial fields improve SABRE efficiency by preserving hydride order.Journal of Magnetic Resonance (San Diego, Calif. : 1997), vol. 342, Aug. 2022, p. 107282. Epmc, doi:10.1016/j.jmr.2022.107282.
Eriksson SL, Mammen MW, Eriksson CW, Lindale JR, Warren WS. Multiaxial fields improve SABRE efficiency by preserving hydride order. Journal of magnetic resonance (San Diego, Calif : 1997). 2022 Aug 5;342:107282.
Journal cover image

Published In

Journal of magnetic resonance (San Diego, Calif. : 1997)

DOI

EISSN

1096-0856

ISSN

1090-7807

Publication Date

August 5, 2022

Volume

342

Start / End Page

107282

Related Subject Headings

  • Protons
  • Magnetic Resonance Spectroscopy
  • Iridium
  • Hydrogen
  • Catalysis
  • Biophysics
  • 51 Physical sciences
  • 40 Engineering
  • 09 Engineering
  • 02 Physical Sciences