Other blood group systems, collections and antigens
This chapter discusses the other types of blood group systems, collections and their antigens. The blood group systems include Chido/Rogers blood group system, Colton blood group system, Cromer blood group system and Diego blood group system among others. The Chido/Rogers blood group system antigens are high-incidence antigens present on the isotypes of the 4th component of complement (C4) and serves as a platform for interaction of the antigen-antibody complex and the complement proteins. The Colton blood group system antigens reside in the RBC water channel protein Aquaporin-1, which also serve as an ion channel. Antibodies to the Colton system are rare and have been implicated in hemolytic transfusion reactions and hemolytic disease of the fetus and newborn. Blood group collections include Cost collection which consists of Csa and Csb and antibodies to these antigens are not clinically significant and the other collection is the Er blood group collection which consists of two antigens, Era and Erb.
