A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.
Publication
, Journal Article
Larisch, S; Yi, Y; Lotan, R; Kerner, H; Eimerl, S; Tony Parks, W; Gottfried, Y; Birkey Reffey, S; de Caestecker, MP; Danielpour, D; Timberg, R ...
Published in: Nat Cell Biol
December 2000
Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-beta signalling pathway). ARTS is expressed in many cells and acts to enhance cell death induced by TGF-beta or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.
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Published In
Nat Cell Biol
DOI
ISSN
1465-7392
Publication Date
December 2000
Volume
2
Issue
12
Start / End Page
915 / 921
Location
England
Related Subject Headings
- Transforming Growth Factor beta
- Transfection
- Signal Transduction
- Sequence Homology, Amino Acid
- Septins
- Molecular Sequence Data
- Mitochondria
- Humans
- Gene Expression
- GTP Phosphohydrolases
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Larisch, S., Yi, Y., Lotan, R., Kerner, H., Eimerl, S., Tony Parks, W., … Roberts, A. B. (2000). A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol, 2(12), 915–921. https://doi.org/10.1038/35046566
Larisch, S., Y. Yi, R. Lotan, H. Kerner, S. Eimerl, W. Tony Parks, Y. Gottfried, et al. “A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.” Nat Cell Biol 2, no. 12 (December 2000): 915–21. https://doi.org/10.1038/35046566.
Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol. 2000 Dec;2(12):915–21.
Larisch, S., et al. “A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif.” Nat Cell Biol, vol. 2, no. 12, Dec. 2000, pp. 915–21. Pubmed, doi:10.1038/35046566.
Larisch S, Yi Y, Lotan R, Kerner H, Eimerl S, Tony Parks W, Gottfried Y, Birkey Reffey S, de Caestecker MP, Danielpour D, Book-Melamed N, Timberg R, Duckett CS, Lechleider RJ, Steller H, Orly J, Kim SJ, Roberts AB. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol. 2000 Dec;2(12):915–921.
Published In
Nat Cell Biol
DOI
ISSN
1465-7392
Publication Date
December 2000
Volume
2
Issue
12
Start / End Page
915 / 921
Location
England
Related Subject Headings
- Transforming Growth Factor beta
- Transfection
- Signal Transduction
- Sequence Homology, Amino Acid
- Septins
- Molecular Sequence Data
- Mitochondria
- Humans
- Gene Expression
- GTP Phosphohydrolases