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IAP proteins: blocking the road to death's door.

Publication ,  Journal Article
Salvesen, GS; Duckett, CS
Published in: Nat Rev Mol Cell Biol
June 2002
Published version (DOI) Link to item

The 'inhibitor of apoptosis' (IAP) gene family, which was discovered less than a decade ago, encodes a group of structurally related proteins that, in addition to their ability to suppress apoptotic cell death, are involved in an increasing number of seemingly unrelated cellular functions. Here, we review the functional and structural properties of this fascinating group of proteins, and of several recently identified IAP-binding factors that regulate IAP function.

Duke Scholars

Colin S Duckett
Author Colin S Duckett Pathology
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Published In

Nat Rev Mol Cell Biol

DOI

10.1038/nrm830

ISSN

1471-0072

Publication Date

June 2002

Volume

3

Issue

6

Start / End Page

401 / 410

Location

England

Related Subject Headings

  • Proteins
  • Insect Proteins
  • Inhibitor of Apoptosis Proteins
  • Humans
  • Gene Expression Regulation
  • Developmental Biology
  • Cysteine Proteinase Inhibitors
  • Binding Sites
  • Apoptosis
  • Animals
 

Citation

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Salvesen, G. S., & Duckett, C. S. (2002). IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol, 3(6), 401–410. https://doi.org/10.1038/nrm830
Salvesen, Guy S., and Colin S. Duckett. “IAP proteins: blocking the road to death's door.” Nat Rev Mol Cell Biol 3, no. 6 (June 2002): 401–10. https://doi.org/10.1038/nrm830.
Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002 Jun;3(6):401–10.
Salvesen, Guy S., and Colin S. Duckett. “IAP proteins: blocking the road to death's door.” Nat Rev Mol Cell Biol, vol. 3, no. 6, June 2002, pp. 401–10. Pubmed, doi:10.1038/nrm830.
Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol. 2002 Jun;3(6):401–410.

Published In

Nat Rev Mol Cell Biol

DOI

10.1038/nrm830

ISSN

1471-0072

Publication Date

June 2002

Volume

3

Issue

6

Start / End Page

401 / 410

Location

England

Related Subject Headings

  • Proteins
  • Insect Proteins
  • Inhibitor of Apoptosis Proteins
  • Humans
  • Gene Expression Regulation
  • Developmental Biology
  • Cysteine Proteinase Inhibitors
  • Binding Sites
  • Apoptosis
  • Animals