A caspase homolog keeps CED-3 in check.
Publication
, Journal Article
Brady, GF; Duckett, CS
Published in: Trends Biochem Sci
March 2009
Apoptosis is a highly conserved form of cell death that is essential for controlling cell numbers throughout the lifetime of an organism. In Caenorhabditis elegans, the final step in the apoptotic cascade is activation of the death-inducing protease CED-3. Until now, no direct negative regulators of CED-3 had been identified, so the mechanism for maintaining a proper life-death balance was unclear. Now, a new study identifies CSP-3 as an important negative regulator of CED-3 during C. elegans development.
Duke Scholars
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
March 2009
Volume
34
Issue
3
Start / End Page
104 / 107
Location
England
Related Subject Headings
- Protein Binding
- Models, Biological
- Enzyme Activation
- Developmental Biology
- Caspases
- Caenorhabditis elegans Proteins
- Caenorhabditis elegans
- Apoptosis
- Animals
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Brady, G. F., & Duckett, C. S. (2009). A caspase homolog keeps CED-3 in check. Trends Biochem Sci, 34(3), 104–107. https://doi.org/10.1016/j.tibs.2008.11.003
Brady, Graham F., and Colin S. Duckett. “A caspase homolog keeps CED-3 in check.” Trends Biochem Sci 34, no. 3 (March 2009): 104–7. https://doi.org/10.1016/j.tibs.2008.11.003.
Brady GF, Duckett CS. A caspase homolog keeps CED-3 in check. Trends Biochem Sci. 2009 Mar;34(3):104–7.
Brady, Graham F., and Colin S. Duckett. “A caspase homolog keeps CED-3 in check.” Trends Biochem Sci, vol. 34, no. 3, Mar. 2009, pp. 104–07. Pubmed, doi:10.1016/j.tibs.2008.11.003.
Brady GF, Duckett CS. A caspase homolog keeps CED-3 in check. Trends Biochem Sci. 2009 Mar;34(3):104–107.
Published In
Trends Biochem Sci
DOI
ISSN
0968-0004
Publication Date
March 2009
Volume
34
Issue
3
Start / End Page
104 / 107
Location
England
Related Subject Headings
- Protein Binding
- Models, Biological
- Enzyme Activation
- Developmental Biology
- Caspases
- Caenorhabditis elegans Proteins
- Caenorhabditis elegans
- Apoptosis
- Animals
- 11 Medical and Health Sciences