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Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma.

Publication ,  Journal Article
Zhang, W; Zhao, H; Chen, J; Zhong, X; Zeng, W; Li, Z; Zhou, J; He, Z; Tang, S
Published in: Life sciences
July 2020

Skin cutaneous melanoma (SKCM) is the most common subtype of skin malignancy, with ever-increasing incidence, mortality, and disease burden. Dysregulation of JAK-STATs signaling pathway is involved in the pathogenesis and progression of cancers, thus affecting the prognosis of cancer patients. The function of JAKs in SKCM is still not clarified.A total of five online portal (GEPIA, TIMER, GeneMANIA, LinkedOmics, and GSCALite) is used to mine the expression and gene regulation network JAK2 in SKCM.JAK2 expression was downregulated in SKCM and significantly associated with pathological stage and the prognosis of patients. The functions of JAK2 and associated genes were primarily involved in the DNA recombination, cell cycle checkpoint, metabolic process, NOD-like receptor signaling pathways, p53 signaling pathway and apoptosis. JAK2 level was significantly correlated with the abundance of immune cells and the level of immune biomarkers. Low expression of JAK2 were resistant to QL-VIII-58, TL-1-85, Ruxolitinib, TG101348 and Sunitinib.Our results reveal the expression and gene regulation network of JAK2 in skin cutaneous melanoma, providing more evidences about the role of JAK2 in carcinogenesis.

Duke Scholars

Published In

Life sciences

DOI

EISSN

1879-0631

ISSN

0024-3205

Publication Date

July 2020

Volume

253

Start / End Page

117600

Related Subject Headings

  • Sunitinib
  • Skin Neoplasms
  • Signal Transduction
  • Pyrimidines
  • Pyrazoles
  • Prognosis
  • Pharmacology & Pharmacy
  • Nitriles
  • Models, Biological
  • MicroRNAs
 

Citation

APA
Chicago
ICMJE
MLA
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Zhang, W., Zhao, H., Chen, J., Zhong, X., Zeng, W., Li, Z., … Tang, S. (2020). Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma. Life Sciences, 253, 117600. https://doi.org/10.1016/j.lfs.2020.117600
Zhang, Wancong, Hanxing Zhao, Jiasheng Chen, Xiaoping Zhong, Weiping Zeng, Zhonglei Li, Jianda Zhou, Zhihao He, and Shijie Tang. “Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma.Life Sciences 253 (July 2020): 117600. https://doi.org/10.1016/j.lfs.2020.117600.
Zhang W, Zhao H, Chen J, Zhong X, Zeng W, Li Z, et al. Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma. Life sciences. 2020 Jul;253:117600.
Zhang, Wancong, et al. “Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma.Life Sciences, vol. 253, July 2020, p. 117600. Epmc, doi:10.1016/j.lfs.2020.117600.
Zhang W, Zhao H, Chen J, Zhong X, Zeng W, Li Z, Zhou J, He Z, Tang S. Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma. Life sciences. 2020 Jul;253:117600.
Journal cover image

Published In

Life sciences

DOI

EISSN

1879-0631

ISSN

0024-3205

Publication Date

July 2020

Volume

253

Start / End Page

117600

Related Subject Headings

  • Sunitinib
  • Skin Neoplasms
  • Signal Transduction
  • Pyrimidines
  • Pyrazoles
  • Prognosis
  • Pharmacology & Pharmacy
  • Nitriles
  • Models, Biological
  • MicroRNAs