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ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.

Publication ,  Journal Article
Zhu, X; Trimarco, JD; Williams, CA; Barrera, A; Reddy, TE; Heaton, NS
Published in: Cell Rep
October 25, 2022

The cellular fate after infection with human coronaviruses (HCoVs) is typically death. Previous data suggest, however, that the transcriptional state of an individual cell may sometimes allow additional outcomes of infection. Here, to probe the range of interactions a permissive cell type can have with a HCoV, we perform a CRISPR activation screen with HCoV-229E. The screen identified the transcription factor ZBTB7A, which strongly promotes cell survival after infection. Rather than suppressing viral infection, ZBTB7A upregulation allows the virus to induce a persistent infection and homeostatic state with the cell. We also find that control of oxidative stress is a primary driver of cellular survival during HCoV-229E infection. These data illustrate that, in addition to the nature of the infecting virus and the type of cell that it encounters, the cellular gene expression profile prior to infection can affect the eventual fate.

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Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

October 25, 2022

Volume

41

Issue

4

Start / End Page

111540

Location

United States

Related Subject Headings

  • Transcription Factors
  • Humans
  • Homeostasis
  • DNA-Binding Proteins
  • Coronavirus 229E, Human
  • Cell Line, Tumor
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
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ICMJE
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Zhu, X., Trimarco, J. D., Williams, C. A., Barrera, A., Reddy, T. E., & Heaton, N. S. (2022). ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. Cell Rep, 41(4), 111540. https://doi.org/10.1016/j.celrep.2022.111540
Zhu, Xinyu, Joseph D. Trimarco, Courtney A. Williams, Alejandro Barrera, Timothy E. Reddy, and Nicholas S. Heaton. “ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.Cell Rep 41, no. 4 (October 25, 2022): 111540. https://doi.org/10.1016/j.celrep.2022.111540.
Zhu X, Trimarco JD, Williams CA, Barrera A, Reddy TE, Heaton NS. ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. Cell Rep. 2022 Oct 25;41(4):111540.
Zhu, Xinyu, et al. “ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection.Cell Rep, vol. 41, no. 4, Oct. 2022, p. 111540. Pubmed, doi:10.1016/j.celrep.2022.111540.
Zhu X, Trimarco JD, Williams CA, Barrera A, Reddy TE, Heaton NS. ZBTB7A promotes virus-host homeostasis during human coronavirus 229E infection. Cell Rep. 2022 Oct 25;41(4):111540.
Journal cover image

Published In

Cell Rep

DOI

EISSN

2211-1247

Publication Date

October 25, 2022

Volume

41

Issue

4

Start / End Page

111540

Location

United States

Related Subject Headings

  • Transcription Factors
  • Humans
  • Homeostasis
  • DNA-Binding Proteins
  • Coronavirus 229E, Human
  • Cell Line, Tumor
  • 31 Biological sciences
  • 1116 Medical Physiology
  • 0601 Biochemistry and Cell Biology