Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Time-restricted feeding mitigates obesity through adipocyte thermogenesis.

Publication ,  Journal Article
Hepler, C; Weidemann, BJ; Waldeck, NJ; Marcheva, B; Cedernaes, J; Thorne, AK; Kobayashi, Y; Nozawa, R; Newman, MV; Gao, P; Shao, M; Ramsey, KM ...
Published in: Science
October 21, 2022

Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting feeding to the active period mitigates metabolic syndrome through mechanisms that remain unknown. We found that genetic enhancement of adipocyte thermogenesis through ablation of the zinc finger protein 423 (ZFP423) attenuated obesity caused by consumption of a high-fat diet during the inactive (light) period by increasing futile creatine cycling in mice. Circadian control of adipocyte creatine metabolism underlies the timing of diet-induced thermogenesis, and enhancement of adipocyte circadian rhythms through overexpression of the clock activator brain and muscle Arnt-like protein-1 (BMAL1) ameliorated metabolic complications during diet-induced obesity. These findings uncover rhythmic creatine-mediated thermogenesis as an essential mechanism that drives metabolic benefits during time-restricted feeding.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Science

DOI

EISSN

1095-9203

Publication Date

October 21, 2022

Volume

378

Issue

6617

Start / End Page

276 / 284

Location

United States

Related Subject Headings

  • Transcription Factors
  • Time Factors
  • Thermogenesis
  • Obesity
  • Mice, Knockout
  • Mice
  • General Science & Technology
  • Diet, High-Fat
  • DNA-Binding Proteins
  • Creatine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hepler, C., Weidemann, B. J., Waldeck, N. J., Marcheva, B., Cedernaes, J., Thorne, A. K., … Bass, J. (2022). Time-restricted feeding mitigates obesity through adipocyte thermogenesis. Science, 378(6617), 276–284. https://doi.org/10.1126/science.abl8007
Hepler, Chelsea, Benjamin J. Weidemann, Nathan J. Waldeck, Biliana Marcheva, Jonathan Cedernaes, Anneke K. Thorne, Yumiko Kobayashi, et al. “Time-restricted feeding mitigates obesity through adipocyte thermogenesis.Science 378, no. 6617 (October 21, 2022): 276–84. https://doi.org/10.1126/science.abl8007.
Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, et al. Time-restricted feeding mitigates obesity through adipocyte thermogenesis. Science. 2022 Oct 21;378(6617):276–84.
Hepler, Chelsea, et al. “Time-restricted feeding mitigates obesity through adipocyte thermogenesis.Science, vol. 378, no. 6617, Oct. 2022, pp. 276–84. Pubmed, doi:10.1126/science.abl8007.
Hepler C, Weidemann BJ, Waldeck NJ, Marcheva B, Cedernaes J, Thorne AK, Kobayashi Y, Nozawa R, Newman MV, Gao P, Shao M, Ramsey KM, Gupta RK, Bass J. Time-restricted feeding mitigates obesity through adipocyte thermogenesis. Science. 2022 Oct 21;378(6617):276–284.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

October 21, 2022

Volume

378

Issue

6617

Start / End Page

276 / 284

Location

United States

Related Subject Headings

  • Transcription Factors
  • Time Factors
  • Thermogenesis
  • Obesity
  • Mice, Knockout
  • Mice
  • General Science & Technology
  • Diet, High-Fat
  • DNA-Binding Proteins
  • Creatine