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GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model.

Publication ,  Journal Article
de Souza, CO; Paschoal, VA; Sun, X; Vishvanath, L; Zhang, Q; Shao, M; Onodera, T; Chen, S; Joffin, N; Bueno, LM; Gupta, RK; Oh, DY
Published in: J Clin Invest
November 1, 2022

The molecular mechanisms underlying obesity-induced increases in β cell mass and the resulting β cell dysfunction need to be elucidated further. Our study revealed that GPR92, expressed in islet macrophages, is modulated by dietary interventions in metabolic tissues. Therefore, we aimed to define the role of GPR92 in islet inflammation by using a high-fat diet-induced (HFD-induced) obese mouse model. GPR92-KO mice exhibited glucose intolerance and reduced insulin levels - despite the enlarged pancreatic islets - as well as increased islet macrophage content and inflammation level compared with WT mice. These results indicate that the lack of GPR92 in islet macrophages can cause β cell dysfunction, leading to disrupted glucose homeostasis. Alternatively, stimulation with the GPR92 agonist farnesyl pyrophosphate results in the inhibition of HFD-induced islet inflammation and increased insulin secretion in WT mice, but not in GPR92-KO mice. Thus, our study suggests that GPR92 can be a potential target to alleviate β cell dysfunction via the inhibition of islet inflammation associated with the progression of diabetes.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

November 1, 2022

Volume

132

Issue

21

Location

United States

Related Subject Headings

  • Obesity
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Macrophages
  • Islets of Langerhans
  • Insulin-Secreting Cells
  • Insulin
  • Inflammation
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
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de Souza, C. O., Paschoal, V. A., Sun, X., Vishvanath, L., Zhang, Q., Shao, M., … Oh, D. Y. (2022). GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model. J Clin Invest, 132(21). https://doi.org/10.1172/JCI160097
Souza, Camila O. de, Vivian A. Paschoal, Xuenan Sun, Lavanya Vishvanath, Qianbin Zhang, Mengle Shao, Toshiharu Onodera, et al. “GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model.J Clin Invest 132, no. 21 (November 1, 2022). https://doi.org/10.1172/JCI160097.
de Souza CO, Paschoal VA, Sun X, Vishvanath L, Zhang Q, Shao M, et al. GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model. J Clin Invest. 2022 Nov 1;132(21).
de Souza, Camila O., et al. “GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model.J Clin Invest, vol. 132, no. 21, Nov. 2022. Pubmed, doi:10.1172/JCI160097.
de Souza CO, Paschoal VA, Sun X, Vishvanath L, Zhang Q, Shao M, Onodera T, Chen S, Joffin N, Bueno LM, Gupta RK, Oh DY. GPR92 activation in islet macrophages controls β cell function in a diet-induced obesity model. J Clin Invest. 2022 Nov 1;132(21).

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

November 1, 2022

Volume

132

Issue

21

Location

United States

Related Subject Headings

  • Obesity
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Macrophages
  • Islets of Langerhans
  • Insulin-Secreting Cells
  • Insulin
  • Inflammation
  • Immunology