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Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.

Publication ,  Journal Article
Her, Z; Kam, Y-W; Gan, VC; Lee, B; Thein, T-L; Tan, JJL; SIgN Immunomonitoring Platform; Lee, LK; Fink, K; Lye, DC; Rénia, L; Leo, Y-S; Ng, LFP
Published in: The Journal of infectious diseases
January 2017

Dengue virus infection typically causes mild dengue fever, but, in severe cases, life-threatening dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) occur. The pathophysiological hallmark of DHF and DSS is plasma leakage that leads to enhanced vascular permeability, likely due to a cytokine storm. Ninety patients with dengue during 2010-2012 in Singapore were prospectively recruited and stratified according to their disease phase, primary and secondary infection status, and disease severity, measured by plasma leakage. Clinical parameters were recorded throughout the disease progression. The levels of various immune mediators were quantified using comprehensive multiplex microbead-based immunoassays for 46 immune mediators. Associations between clinical parameters and immune mediators were analyzed using various statistical methods. Potential immune markers, including interleukin 1 receptor antagonist, interferon γ-inducible protein 10, hepatocyte growth factor, soluble p75 tumor necrosis factor α receptor, vascular cell adhesion molecule 1, and matrix metalloproteinase 2, were significantly associated with significant plasma leakage. Secondary dengue virus infections were also shown to influence disease outcome in terms of disease severity. This study identified several key markers for exacerbated dengue pathogenesis, notably plasma leakage. This will allow a better understanding of the molecular mechanisms of DHF and DSS in patients with dengue.

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Published In

The Journal of infectious diseases

DOI

EISSN

1537-6613

ISSN

0022-1899

Publication Date

January 2017

Volume

215

Issue

1

Start / End Page

42 / 51

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • Singapore
  • Severe Dengue
  • Serogroup
  • Receptors, Tumor Necrosis Factor
  • Middle Aged
  • Microbiology
  • Matrix Metalloproteinases
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 2
 

Citation

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Her, Z., Kam, Y.-W., Gan, V. C., Lee, B., Thein, T.-L., Tan, J. J. L., … Ng, L. F. P. (2017). Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection. The Journal of Infectious Diseases, 215(1), 42–51. https://doi.org/10.1093/infdis/jiw494
Her, Zhisheng, Yiu-Wing Kam, Victor C. Gan, Bernett Lee, Tun-Linn Thein, Jeslin J. L. Tan, SIgN Immunomonitoring Platform, et al. “Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.The Journal of Infectious Diseases 215, no. 1 (January 2017): 42–51. https://doi.org/10.1093/infdis/jiw494.
Her, Zhisheng, et al. “Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection.The Journal of Infectious Diseases, vol. 215, no. 1, Jan. 2017, pp. 42–51. Epmc, doi:10.1093/infdis/jiw494.
Her Z, Kam Y-W, Gan VC, Lee B, Thein T-L, Tan JJL, SIgN Immunomonitoring Platform, Lee LK, Fink K, Lye DC, Rénia L, Leo Y-S, Ng LFP. Severity of Plasma Leakage Is Associated With High Levels of Interferon γ-Inducible Protein 10, Hepatocyte Growth Factor, Matrix Metalloproteinase 2 (MMP-2), and MMP-9 During Dengue Virus Infection. The Journal of infectious diseases. 2017 Jan;215(1):42–51.
Journal cover image

Published In

The Journal of infectious diseases

DOI

EISSN

1537-6613

ISSN

0022-1899

Publication Date

January 2017

Volume

215

Issue

1

Start / End Page

42 / 51

Related Subject Headings

  • Vascular Cell Adhesion Molecule-1
  • Singapore
  • Severe Dengue
  • Serogroup
  • Receptors, Tumor Necrosis Factor
  • Middle Aged
  • Microbiology
  • Matrix Metalloproteinases
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 2