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Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy.

Publication ,  Journal Article
Josephson, GD; Bradshaw, JB; Roohani, C; Hossain, J; Andreoli, SM; Lang, JE
Published in: Ear Nose Throat J
December 1, 2022

OBJECTIVES: Childhood adenotonsillar hypertrophy (ATH) with sleep-disordered breathing (SDB) frequently occurs concomitant with asthma. Adenotonsillectomy and reduction in asthma severity association has been reported. We describe changes in asthma control in nonobese or normal weight and obese/overweight children undergoing adenotonsillectomy for SDB. METHODS: This prospective, nonrandomized cohort trial with 6-month follow-up at a tertiary children's hospital enrolled 41 children with persistent asthma undergoing adenotonsillectomy for SDB. Children with significant chronic medical conditions, premature birth (< 28 weeks), or recent respiratory infection were excluded. Patients were stratified by baseline BMI into nonobese or normal weight (BMI < 85 percentile) and obese/overweight (BMI > 85%). The primary outcome was change in Childhood Asthma Control Test (cACT) scores 3 and 6 months following adenotonsillectomy. Secondary outcome examined improvement in Pediatric Asthma Caregiver's Quality of Life Questionnaire (PACQLQ) 3 and 6 months following adenotonsillectomy. RESULTS: Baseline characteristics were similar except for anthropometric measures and mean PACQLQ (P = .03). Children with nonobese or normal weight (n = 26) had statistically significant improvement in change in cACT at 3 (22.80 ± 2.33 vs. 17.86 ± 3.53, P < .001) and 6 (20.71±3.29 vs. 18.24 ± 4.16, P = .044) months compared with baseline. PACQLQ scores also improved at 3 (6.20 ± 0.87 vs. 4.56 ± 1.12, P < .001) and 6 (6.36 ± 0.72 vs. 4.93 ± 0.96, P < .001) months. Obese/overweight children (n = 10) had significant improvement in cACT scores at 6 months (20.00 ± 3.90 vs. 15.00 ± 6.90, P = .048). Change of cACT scores at 3 months (17.86 ± 3.53 vs. 14.86 ± 6.31, P = .272) was not significantly different. PACQLQ scores improved at 3 (5.47 ± 1.09 vs. 3.70 ± 0.85, P < .001) and 6 (5.75 ± 2.19 vs. 3.67 ± 1.04, P = .016) months. CONCLUSION: Nonobese or normal-weight children undergoing adenotonsillectomy demonstrated significant improvement in asthma control scores at 3 and 6 and obese/overweight children at 6 months. Using the PACQLQ, caregiver quality of life improved for all children at 3 and 6 months. Surgical management of ATH in children with comorbid SBD and asthma is a good treatment option.

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Published In

Ear Nose Throat J

DOI

EISSN

1942-7522

Publication Date

December 1, 2022

Start / End Page

1455613221101085

Location

United States

Related Subject Headings

  • Otorhinolaryngology
  • 4201 Allied health and rehabilitation science
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

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Josephson, G. D., Bradshaw, J. B., Roohani, C., Hossain, J., Andreoli, S. M., & Lang, J. E. (2022). Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy. Ear Nose Throat J, 1455613221101085. https://doi.org/10.1177/01455613221101085
Josephson, Gary D., Joshua B. Bradshaw, Cheyenne Roohani, Jobayer Hossain, Steven M. Andreoli, and Jason E. Lang. “Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy.Ear Nose Throat J, December 1, 2022, 1455613221101085. https://doi.org/10.1177/01455613221101085.
Josephson GD, Bradshaw JB, Roohani C, Hossain J, Andreoli SM, Lang JE. Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy. Ear Nose Throat J. 2022 Dec 1;1455613221101085.
Josephson, Gary D., et al. “Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy.Ear Nose Throat J, Dec. 2022, p. 1455613221101085. Pubmed, doi:10.1177/01455613221101085.
Josephson GD, Bradshaw JB, Roohani C, Hossain J, Andreoli SM, Lang JE. Asthma control in normal weight and overweight/obese asthmatic children following adenotonsillectomy. Ear Nose Throat J. 2022 Dec 1;1455613221101085.

Published In

Ear Nose Throat J

DOI

EISSN

1942-7522

Publication Date

December 1, 2022

Start / End Page

1455613221101085

Location

United States

Related Subject Headings

  • Otorhinolaryngology
  • 4201 Allied health and rehabilitation science
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1103 Clinical Sciences