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Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways.

Publication ,  Journal Article
Rabinovich, GA; Conejo-García, JR
Published in: J Mol Biol
August 14, 2016

Along with the discovery of tumor-driven inflammatory pathways, there has been a considerable progress over the past 10years in understanding the mechanisms leading to cancer immunosurveillance and immunoediting. Several regulatory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effective antitumor responses. These regulatory circuits include the engagement of inhibitory checkpoint pathways (CTLA-4, PD-1/PD-L1, LAG-3 and TIM-3), secretion of immunosuppressive cytokines (TGF-β, IL-10), and expansion and/or recruitment of myeloid or lymphoid regulatory cell populations. Elucidation of these pathways has inspired the design and implementation of novel immunotherapeutic modalities, which have already generated clinical benefits in an important number of cancer patients. Galectins, a family of glycan-binding proteins widely expressed in the tumor microenvironment (TME), have emerged as key players in immune evasion programs that differentially control the fate of effector and regulatory lymphoid and myeloid cell populations. How do galectins translate glycan-containing information into cellular programs that control immune regulatory cancer networks? Here, we uncover the selective roles of individual members of the galectin family in cancer-promoting inflammation, immunosuppression, and angiogenesis. Moreover, we highlight the relevance of corresponding glycosylated ligands and counter-receptors and the emerging function of these lectins as biological liaisons connecting commensal microbiota, systemic inflammation, and distal tumor growth. Understanding the molecular and cellular components of galectin-driven regulatory circuits, the implications of different glycosylation pathways in their functions and their clinical relevance in human cancer might lead to the development of new therapeutic approaches in a broad range of tumor types.

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Published In

J Mol Biol

DOI

EISSN

1089-8638

Publication Date

August 14, 2016

Volume

428

Issue

16

Start / End Page

3266 / 3281

Location

Netherlands

Related Subject Headings

  • Tumor Microenvironment
  • Signal Transduction
  • Neoplasms
  • Ligands
  • Humans
  • Glycosylation
  • Galectins
  • Biochemistry & Molecular Biology
  • Animals
  • 3107 Microbiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rabinovich, G. A., & Conejo-García, J. R. (2016). Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways. J Mol Biol, 428(16), 3266–3281. https://doi.org/10.1016/j.jmb.2016.03.021
Rabinovich, Gabriel A., and José R. Conejo-García. “Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways.J Mol Biol 428, no. 16 (August 14, 2016): 3266–81. https://doi.org/10.1016/j.jmb.2016.03.021.
Rabinovich GA, Conejo-García JR. Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways. J Mol Biol. 2016 Aug 14;428(16):3266–81.
Rabinovich, Gabriel A., and José R. Conejo-García. “Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways.J Mol Biol, vol. 428, no. 16, Aug. 2016, pp. 3266–81. Pubmed, doi:10.1016/j.jmb.2016.03.021.
Rabinovich GA, Conejo-García JR. Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways. J Mol Biol. 2016 Aug 14;428(16):3266–3281.

Published In

J Mol Biol

DOI

EISSN

1089-8638

Publication Date

August 14, 2016

Volume

428

Issue

16

Start / End Page

3266 / 3281

Location

Netherlands

Related Subject Headings

  • Tumor Microenvironment
  • Signal Transduction
  • Neoplasms
  • Ligands
  • Humans
  • Glycosylation
  • Galectins
  • Biochemistry & Molecular Biology
  • Animals
  • 3107 Microbiology