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Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy.

Publication ,  Journal Article
Toraya-Brown, S; Sheen, MR; Baird, JR; Barry, S; Demidenko, E; Turk, MJ; Hoopes, PJ; Conejo-Garcia, JR; Fiering, S
Published in: Integr Biol (Camb)
January 2013

Nanotechnology has great potential to produce novel therapeutic strategies that target malignant cells through the ability of nanoparticles to get access to and be ingested by living cells. However its specificity for accumulation in tumors, which is the key factor that determines its efficacy, has always been a challenge. Here we tested a novel strategy to target and treat ovarian cancer, a representative peritoneal cancer, using iron oxide nanoparticles (IONPs) and an alternating magnetic field (AMF). Peritoneal tumors in general are directly accessible to nanoparticles administered intraperitoneally (IP), as opposed to the more commonly attempted intravenous (IV) administration. In addition, tumor-associated immunosuppressive phagocytes, a predominant cell population in the tumor microenvironment of almost all solid tumors, and cells that are critical for tumor progression, are constantly recruited to the tumor, and therefore could possibly function to bring nanoparticles to tumors. Here we demonstrate that tumor-associated peritoneal phagocytes ingest and carry IONPs specifically to tumors and that these specifically delivered nanoparticles can damage tumor cells after IONP-mediated hyperthermia generated by AMF. This illustrates therapeutic possibilities of intraperitoneal (IP) injection of nanoparticles and subsequent ingestion by tumor-associated phagocytes, to directly impact tumors or stimulate antitumor immune responses. This approach could use IONPs combined with AMF as done here, or other nanoparticles with cytotoxic potential. Overall, the data presented here support IP injection of nanoparticles to utilize peritoneal phagocytes as a delivery vehicle in association with IONP-mediated hyperthermia as therapeutic strategies for ovarian and other peritoneal cancers.

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Published In

Integr Biol (Camb)

DOI

EISSN

1757-9708

Publication Date

January 2013

Volume

5

Issue

1

Start / End Page

159 / 171

Location

England

Related Subject Headings

  • Treatment Outcome
  • Phagocytes
  • Ovarian Neoplasms
  • Mice, Inbred C57BL
  • Mice
  • Magnetite Nanoparticles
  • Magnetic Field Therapy
  • Hyperthermia, Induced
  • General Science & Technology
  • Female
 

Citation

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Chicago
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Toraya-Brown, S., Sheen, M. R., Baird, J. R., Barry, S., Demidenko, E., Turk, M. J., … Fiering, S. (2013). Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr Biol (Camb), 5(1), 159–171. https://doi.org/10.1039/c2ib20180a
Toraya-Brown, Seiko, Mee Rie Sheen, Jason R. Baird, Stephen Barry, Eugene Demidenko, Mary Jo Turk, P Jack Hoopes, Jose R. Conejo-Garcia, and Steven Fiering. “Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy.Integr Biol (Camb) 5, no. 1 (January 2013): 159–71. https://doi.org/10.1039/c2ib20180a.
Toraya-Brown S, Sheen MR, Baird JR, Barry S, Demidenko E, Turk MJ, et al. Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr Biol (Camb). 2013 Jan;5(1):159–71.
Toraya-Brown, Seiko, et al. “Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy.Integr Biol (Camb), vol. 5, no. 1, Jan. 2013, pp. 159–71. Pubmed, doi:10.1039/c2ib20180a.
Toraya-Brown S, Sheen MR, Baird JR, Barry S, Demidenko E, Turk MJ, Hoopes PJ, Conejo-Garcia JR, Fiering S. Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy. Integr Biol (Camb). 2013 Jan;5(1):159–171.
Journal cover image

Published In

Integr Biol (Camb)

DOI

EISSN

1757-9708

Publication Date

January 2013

Volume

5

Issue

1

Start / End Page

159 / 171

Location

England

Related Subject Headings

  • Treatment Outcome
  • Phagocytes
  • Ovarian Neoplasms
  • Mice, Inbred C57BL
  • Mice
  • Magnetite Nanoparticles
  • Magnetic Field Therapy
  • Hyperthermia, Induced
  • General Science & Technology
  • Female