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Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes.

Publication ,  Journal Article
Cubillos-Ruiz, JR; Rutkowski, M; Conejo-Garcia, JR
Published in: Cell Cycle
January 15, 2010

Current therapies for metastatic ovarian carcinoma are based on surgical debulking followed by chemotherapy. After more than three decades implementing treatments that selectively target the tumor cell, the 5-year survival rate for metastatic ovarian cancer patients is still lower than 30%. Novel strategies are therefore urgently needed to complement classical treatments for this malignancy. Recently, leukocytes in the ovarian cancer microenvironment such as regulatory T cells and immature pro-angiogenic/tolerogenic myeloid cells have been demonstrated to play a fundamental role in tumor progression. This review focuses on our recent understanding of the potential of eliminating and/or modulating the phenotype of these leukocytes in vivo and in situ as a novel intervention to complement standard ovarian cancer treatments. The significant effects of targeting these crucial microenvironmental players on cancer vascularization, local tumor growth, distal metastatic spreading and spontaneous anti-tumor immune responses are discussed.

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Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

January 15, 2010

Volume

9

Issue

2

Start / End Page

260 / 268

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • T-Lymphocytes, Regulatory
  • Ovarian Neoplasms
  • Leukocytes
  • Interleukin-10
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Humans
  • Female
  • Disease Progression
  • Developmental Biology
 

Citation

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Cubillos-Ruiz, J. R., Rutkowski, M., & Conejo-Garcia, J. R. (2010). Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes. Cell Cycle, 9(2), 260–268. https://doi.org/10.4161/cc.9.2.10430
Cubillos-Ruiz, Juan R., Melanie Rutkowski, and Jose R. Conejo-Garcia. “Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes.Cell Cycle 9, no. 2 (January 15, 2010): 260–68. https://doi.org/10.4161/cc.9.2.10430.
Cubillos-Ruiz JR, Rutkowski M, Conejo-Garcia JR. Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes. Cell Cycle. 2010 Jan 15;9(2):260–8.
Cubillos-Ruiz, Juan R., et al. “Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes.Cell Cycle, vol. 9, no. 2, Jan. 2010, pp. 260–68. Pubmed, doi:10.4161/cc.9.2.10430.
Cubillos-Ruiz JR, Rutkowski M, Conejo-Garcia JR. Blocking ovarian cancer progression by targeting tumor microenvironmental leukocytes. Cell Cycle. 2010 Jan 15;9(2):260–268.

Published In

Cell Cycle

DOI

EISSN

1551-4005

Publication Date

January 15, 2010

Volume

9

Issue

2

Start / End Page

260 / 268

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta
  • T-Lymphocytes, Regulatory
  • Ovarian Neoplasms
  • Leukocytes
  • Interleukin-10
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Humans
  • Female
  • Disease Progression
  • Developmental Biology