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Antioxidant nutrients protect against cyclosporine A nephrotoxicity.

Publication ,  Journal Article
Parra Cid, T; Conejo García, JR; Carballo Alvarez, F; de Arriba, G
Published in: Toxicology
July 15, 2003

The immunosuppressive drug cyclosporine A (CsA) has been successfully used in several diseases with immunological basis and in transplant patients. Nephrotoxicity is the main secondary effect of CsA treatment. Although the mechanisms of nephrotoxitity are not completely defined, there is evidence that suggests the role of reactive oxygen species (ROS) in its pathogenesis. It has been demonstrated in numerous in vivo and in vitro experiments that CsA induced renal failure and increased the synthesis of ROS, thromboxane (TX) and lipid peroxidation products in the kidney. Furthermore, CsA modified the expression and activity of several renal enzymes (ciclooxygenase, superoxide-dismutase, catalase and glutathione-peroxidase). Antioxidant nutrients (e.g. Vitamins E and C) can neutralize some of the effects that CsA produced in the kidney. Thus, Vit E inhibited the synthesis of ROS and TX and the lipid peroxidation process induced by CsA in kidney structures. Antioxidants can also improve renal function and histological damage produced by CsA administration. Although there are few data in humans treated with CsA, the possibility exists that antioxidants can also neutralize CsA nephrotoxicity and LDL oxidation. Thus, antioxidant nutrients could have a therapeutic role in transplant patients treated with CsA.

Duke Scholars

Published In

Toxicology

DOI

ISSN

0300-483X

Publication Date

July 15, 2003

Volume

189

Issue

1-2

Start / End Page

99 / 111

Location

Ireland

Related Subject Headings

  • Vitamin E
  • Toxicology
  • Thromboxanes
  • Reactive Oxygen Species
  • Lipid Peroxides
  • Kidney Transplantation
  • Kidney Diseases
  • Immunosuppressive Agents
  • Humans
  • Glomerular Filtration Rate
 

Citation

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ICMJE
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Parra Cid, T., Conejo García, J. R., Carballo Alvarez, F., & de Arriba, G. (2003). Antioxidant nutrients protect against cyclosporine A nephrotoxicity. Toxicology, 189(1–2), 99–111. https://doi.org/10.1016/s0300-483x(03)00156-2
Parra Cid, T., J. R. Conejo García, F. Carballo Alvarez, and G. de Arriba. “Antioxidant nutrients protect against cyclosporine A nephrotoxicity.Toxicology 189, no. 1–2 (July 15, 2003): 99–111. https://doi.org/10.1016/s0300-483x(03)00156-2.
Parra Cid T, Conejo García JR, Carballo Alvarez F, de Arriba G. Antioxidant nutrients protect against cyclosporine A nephrotoxicity. Toxicology. 2003 Jul 15;189(1–2):99–111.
Parra Cid, T., et al. “Antioxidant nutrients protect against cyclosporine A nephrotoxicity.Toxicology, vol. 189, no. 1–2, July 2003, pp. 99–111. Pubmed, doi:10.1016/s0300-483x(03)00156-2.
Parra Cid T, Conejo García JR, Carballo Alvarez F, de Arriba G. Antioxidant nutrients protect against cyclosporine A nephrotoxicity. Toxicology. 2003 Jul 15;189(1–2):99–111.
Journal cover image

Published In

Toxicology

DOI

ISSN

0300-483X

Publication Date

July 15, 2003

Volume

189

Issue

1-2

Start / End Page

99 / 111

Location

Ireland

Related Subject Headings

  • Vitamin E
  • Toxicology
  • Thromboxanes
  • Reactive Oxygen Species
  • Lipid Peroxides
  • Kidney Transplantation
  • Kidney Diseases
  • Immunosuppressive Agents
  • Humans
  • Glomerular Filtration Rate