The role of dendritic cell precursors in tumour vasculogenesis.
Publication
, Journal Article
Coukos, G; Benencia, F; Buckanovich, RJ; Conejo-Garcia, JR
Published in: Br J Cancer
April 11, 2005
In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into functional blood vessels or act as antigen-presenting cells. The identification of dendritic cell precursors as bipotent cells has important implications for the physiopathology and therapy of tumours. VLCs emerge as a novel therapeutic target against tumour vascularisation.
Duke Scholars
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Published In
Br J Cancer
DOI
ISSN
0007-0920
Publication Date
April 11, 2005
Volume
92
Issue
7
Start / End Page
1182 / 1187
Location
England
Related Subject Headings
- Vascular Endothelial Growth Factor A
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Neoplasms
- Leukocytes
- Immunotherapy
- Humans
- Dendritic Cells
- Cell Differentiation
- CD11c Antigen
Citation
APA
Chicago
ICMJE
MLA
NLM
Coukos, G., Benencia, F., Buckanovich, R. J., & Conejo-Garcia, J. R. (2005). The role of dendritic cell precursors in tumour vasculogenesis. Br J Cancer, 92(7), 1182–1187. https://doi.org/10.1038/sj.bjc.6602476
Published In
Br J Cancer
DOI
ISSN
0007-0920
Publication Date
April 11, 2005
Volume
92
Issue
7
Start / End Page
1182 / 1187
Location
England
Related Subject Headings
- Vascular Endothelial Growth Factor A
- Oncology & Carcinogenesis
- Neovascularization, Pathologic
- Neoplasms
- Leukocytes
- Immunotherapy
- Humans
- Dendritic Cells
- Cell Differentiation
- CD11c Antigen