Skip to main content

Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.

Publication ,  Journal Article
Bak, SP; Walters, JJ; Takeya, M; Conejo-Garcia, JR; Berwin, BL
Published in: Cancer Res
May 15, 2007

Immunosuppressive leukocytes are emerging as a critical factor in facilitating tumor progression. These leukocytes are converted by the tumor microenvironment to become tolerogenic, facilitate metastasis, and to aid in neovascularization. The predominant variety of suppressive leukocytes found in human and murine ovarian cancer are called vascular leukocytes (VLC), due to sharing functions and cell surface markers of both dendritic cells and endothelial cells. Using the ID8 murine model of ovarian cancer, the aim of this study was to test the efficacy of VLC elimination as an ovarian tumor therapy. We show that carrageenan-mediated depletion of peritoneal tumor-associated leukocytes inhibits ovarian tumor progression. We then identified scavenger receptor-A (SR-A) as a cell surface receptor that is robustly and specifically expressed within human and murine ovarian tumor ascites upon VLCs. Administration of anti-SR-A immunotoxin to mice challenged with peritoneal ID8 tumors eliminated tumor-associated VLCs and, importantly, substantially inhibited peritoneal tumor burden and ascites accumulation. Moreover, the toxin required targeting to SR-A because mice that received untargeted toxin did not exhibit inhibition of tumor progression. We conclude that SR-A constitutes a novel and specific target for efficacious immunotherapeutic treatment of peritoneal ovarian cancer.

Duke Scholars

Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

May 15, 2007

Volume

67

Issue

10

Start / End Page

4783 / 4789

Location

United States

Related Subject Headings

  • Scavenger Receptors, Class A
  • Peritoneal Neoplasms
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Mice
  • Leukocytes
  • Immunotoxins
  • Humans
  • Female
  • Disease Progression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bak, S. P., Walters, J. J., Takeya, M., Conejo-Garcia, J. R., & Berwin, B. L. (2007). Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Cancer Res, 67(10), 4783–4789. https://doi.org/10.1158/0008-5472.CAN-06-4410
Bak, S Peter, Julie Jo Walters, Motohiro Takeya, Jose R. Conejo-Garcia, and Brent L. Berwin. “Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.Cancer Res 67, no. 10 (May 15, 2007): 4783–89. https://doi.org/10.1158/0008-5472.CAN-06-4410.
Bak SP, Walters JJ, Takeya M, Conejo-Garcia JR, Berwin BL. Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Cancer Res. 2007 May 15;67(10):4783–9.
Bak, S. Peter, et al. “Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression.Cancer Res, vol. 67, no. 10, May 2007, pp. 4783–89. Pubmed, doi:10.1158/0008-5472.CAN-06-4410.
Bak SP, Walters JJ, Takeya M, Conejo-Garcia JR, Berwin BL. Scavenger receptor-A-targeted leukocyte depletion inhibits peritoneal ovarian tumor progression. Cancer Res. 2007 May 15;67(10):4783–4789.

Published In

Cancer Res

DOI

ISSN

0008-5472

Publication Date

May 15, 2007

Volume

67

Issue

10

Start / End Page

4783 / 4789

Location

United States

Related Subject Headings

  • Scavenger Receptors, Class A
  • Peritoneal Neoplasms
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Mice
  • Leukocytes
  • Immunotoxins
  • Humans
  • Female
  • Disease Progression