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Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

Publication ,  Journal Article
Zhang, L; Conejo-Garcia, JR; Katsaros, D; Gimotty, PA; Massobrio, M; Regnani, G; Makrigiannakis, A; Gray, H; Schlienger, K; Liebman, MN ...
Published in: N Engl J Med
January 16, 2003

BACKGROUND: Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established. METHODS: We performed immunohistochemical analysis of 186 frozen specimens from advanced-stage ovarian carcinomas to assess the distribution of tumor-infiltrating T cells and conducted outcome analyses. Molecular analyses were performed in some tumors by real-time polymerase chain reaction. RESULTS: CD3+ tumor-infiltrating T cells were detected within tumor-cell islets (intratumoral T cells) in 102 of the 186 tumors (54.8 percent); they were undetectable in 72 tumors (38.7 percent); the remaining 12 tumors (6.5 percent) could not be evaluated. There were significant differences in the distributions of progression-free survival and overall survival according to the presence or absence of intratumoral T cells (P<0.001 for both comparisons). The five-year overall survival rate was 38.0 percent among patients whose tumors contained T cells and 4.5 percent among patients whose tumors contained no T cells in islets. Significant differences in the distributions of progression-free survival and overall survival according to the presence or absence of intratumoral T cells (P<0.001 for both comparisons) were also seen among 74 patients with a complete clinical response after debulking and platinum-based chemotherapy: the five-year overall survival rate was 73.9 percent among patients whose tumors contained T cells and 11.9 percent among patients whose tumors contained no T cells in islets. The presence of intratumoral T cells independently correlated with delayed recurrence or delayed death in multivariate analysis and was associated with increased expression of interferon-gamma, interleukin-2, and lymphocyte-attracting chemokines within the tumor. The absence of intratumoral T cells was associated with increased levels of vascular endothelial growth factor. CONCLUSIONS: The presence of intratumoral T cells correlates with improved clinical outcome in advanced ovarian carcinoma.

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Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

January 16, 2003

Volume

348

Issue

3

Start / End Page

203 / 213

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Survival Analysis
  • Polymerase Chain Reaction
  • Ovarian Neoplasms
  • Neoplasm Recurrence, Local
  • Multivariate Analysis
  • Middle Aged
  • Lymphocytes, Tumor-Infiltrating
  • Immunohistochemistry
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., … Coukos, G. (2003). Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med, 348(3), 203–213. https://doi.org/10.1056/NEJMoa020177
Zhang, Lin, Jose R. Conejo-Garcia, Dionyssios Katsaros, Phyllis A. Gimotty, Marco Massobrio, Giorgia Regnani, Antonis Makrigiannakis, et al. “Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.N Engl J Med 348, no. 3 (January 16, 2003): 203–13. https://doi.org/10.1056/NEJMoa020177.
Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003 Jan 16;348(3):203–13.
Zhang, Lin, et al. “Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.N Engl J Med, vol. 348, no. 3, Jan. 2003, pp. 203–13. Pubmed, doi:10.1056/NEJMoa020177.
Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman MN, Rubin SC, Coukos G. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003 Jan 16;348(3):203–213.

Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

January 16, 2003

Volume

348

Issue

3

Start / End Page

203 / 213

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Survival Analysis
  • Polymerase Chain Reaction
  • Ovarian Neoplasms
  • Neoplasm Recurrence, Local
  • Multivariate Analysis
  • Middle Aged
  • Lymphocytes, Tumor-Infiltrating
  • Immunohistochemistry
  • Humans