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Vascular leukocytes contribute to tumor vascularization.

Publication ,  Journal Article
Conejo-Garcia, JR; Buckanovich, RJ; Benencia, F; Courreges, MC; Rubin, SC; Carroll, RG; Coukos, G
Published in: Blood
January 15, 2005

There is no proof that hematopoietic cells contribute significantly to vasculogenesis in postnatal life. Here we report a novel leukocyte subset within ovarian carcinoma that coexpresses endothelial and dendritic cell markers. Fluorescence-activated cell sorter (FACS) analysis identified a high frequency of VE-cadherin+ CD45+ leukocytes (39% of host cells) in 10 of 10 solid tumors evaluated. This population represented less than 1% of nontumor cells in ascites and peripheral blood. At the protein level, more than 86% of these cells expressed the endothelial markers P1H12, CD34, and CD31 and leukocyte markers CD11c and major histocompatibility complex (MHC) class II. At the mRNA level, we detected TEM1, TEM7, and Thy-1, specific markers of angiogenic endothelium. Finally, this population has the capacity to generate functional blood vessels in vivo. Because of its mixed phenotype, we named this population vascular leukocytes (VLCs). Our data provide an important link between hematopoietic endothelial precursors and vascular development in postnatal life and a possible novel therapeutic target.

Duke Scholars

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Published In

Blood

DOI

ISSN

0006-4971

Publication Date

January 15, 2005

Volume

105

Issue

2

Start / End Page

679 / 681

Location

United States

Related Subject Headings

  • Stem Cells
  • Ovarian Neoplasms
  • Neovascularization, Pathologic
  • Mice, SCID
  • Mice, Inbred BALB C
  • Mice
  • Leukocytes
  • Leukocyte Common Antigens
  • Immunology
  • Humans
 

Citation

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Conejo-Garcia, J. R., Buckanovich, R. J., Benencia, F., Courreges, M. C., Rubin, S. C., Carroll, R. G., & Coukos, G. (2005). Vascular leukocytes contribute to tumor vascularization. Blood, 105(2), 679–681. https://doi.org/10.1182/blood-2004-05-1906
Conejo-Garcia, Jose R., Ronald J. Buckanovich, Fabian Benencia, Maria C. Courreges, Stephen C. Rubin, Richard G. Carroll, and George Coukos. “Vascular leukocytes contribute to tumor vascularization.Blood 105, no. 2 (January 15, 2005): 679–81. https://doi.org/10.1182/blood-2004-05-1906.
Conejo-Garcia JR, Buckanovich RJ, Benencia F, Courreges MC, Rubin SC, Carroll RG, et al. Vascular leukocytes contribute to tumor vascularization. Blood. 2005 Jan 15;105(2):679–81.
Conejo-Garcia, Jose R., et al. “Vascular leukocytes contribute to tumor vascularization.Blood, vol. 105, no. 2, Jan. 2005, pp. 679–81. Pubmed, doi:10.1182/blood-2004-05-1906.
Conejo-Garcia JR, Buckanovich RJ, Benencia F, Courreges MC, Rubin SC, Carroll RG, Coukos G. Vascular leukocytes contribute to tumor vascularization. Blood. 2005 Jan 15;105(2):679–681.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

January 15, 2005

Volume

105

Issue

2

Start / End Page

679 / 681

Location

United States

Related Subject Headings

  • Stem Cells
  • Ovarian Neoplasms
  • Neovascularization, Pathologic
  • Mice, SCID
  • Mice, Inbred BALB C
  • Mice
  • Leukocytes
  • Leukocyte Common Antigens
  • Immunology
  • Humans