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Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A.

Publication ,  Journal Article
Conejo-Garcia, JR; Benencia, F; Courreges, M-C; Kang, E; Mohamed-Hadley, A; Buckanovich, RJ; Holtz, DO; Jenkins, A; Na, H; Zhang, L; Wagner, DS ...
Published in: Nat Med
September 2004

The involvement of immune mechanisms in tumor angiogenesis is unclear. Here we describe a new mechanism of tumor vasculogenesis mediated by dendritic cell (DC) precursors through the cooperation of beta-defensins and vascular endothelial growth factor-A (Vegf-A). Expression of mouse beta-defensin-29 recruited DC precursors to tumors and enhanced tumor vascularization and growth in the presence of increased Vegf-A expression. A new leukocyte population expressing DC and endothelial markers was uncovered in mouse and human ovarian carcinomas coexpressing Vegf-A and beta-defensins. Tumor-infiltrating DCs migrated to tumor vessels and independently assembled neovasculature in vivo. Bone marrow-derived DCs underwent endothelial-like differentiation ex vivo, migrated to blood vessels and promoted the growth of tumors expressing high levels of Vegf-A. We show that beta-defensins and Vegf-A cooperate to promote tumor vasculogenesis by carrying out distinct tasks: beta-defensins chemoattract DC precursors through CCR6, whereas Vegf-A primarily induces their endothelial-like specialization and migration to vessels, which is mediated by Vegf receptor-2.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 2004

Volume

10

Issue

9

Start / End Page

950 / 958

Location

United States

Related Subject Headings

  • beta-Defensins
  • Vascular Endothelial Growth Factor A
  • Receptors, Chemokine
  • Proteoglycans
  • Neovascularization, Pathologic
  • Mice
  • Laminin
  • Immunology
  • Immunoblotting
  • Histological Techniques
 

Citation

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Conejo-Garcia, J. R., Benencia, F., Courreges, M.-C., Kang, E., Mohamed-Hadley, A., Buckanovich, R. J., … Coukos, G. (2004). Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med, 10(9), 950–958. https://doi.org/10.1038/nm1097
Conejo-Garcia, Jose R., Fabian Benencia, Maria-Cecilia Courreges, Eugene Kang, Alisha Mohamed-Hadley, Ronald J. Buckanovich, David O. Holtz, et al. “Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A.Nat Med 10, no. 9 (September 2004): 950–58. https://doi.org/10.1038/nm1097.
Conejo-Garcia JR, Benencia F, Courreges M-C, Kang E, Mohamed-Hadley A, Buckanovich RJ, et al. Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med. 2004 Sep;10(9):950–8.
Conejo-Garcia, Jose R., et al. “Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A.Nat Med, vol. 10, no. 9, Sept. 2004, pp. 950–58. Pubmed, doi:10.1038/nm1097.
Conejo-Garcia JR, Benencia F, Courreges M-C, Kang E, Mohamed-Hadley A, Buckanovich RJ, Holtz DO, Jenkins A, Na H, Zhang L, Wagner DS, Katsaros D, Caroll R, Coukos G. Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A. Nat Med. 2004 Sep;10(9):950–958.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 2004

Volume

10

Issue

9

Start / End Page

950 / 958

Location

United States

Related Subject Headings

  • beta-Defensins
  • Vascular Endothelial Growth Factor A
  • Receptors, Chemokine
  • Proteoglycans
  • Neovascularization, Pathologic
  • Mice
  • Laminin
  • Immunology
  • Immunoblotting
  • Histological Techniques