Skip to main content

Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity.

Publication ,  Journal Article
Parra, T; de Arriba, G; Conejo, JR; Cantero, M; Arribas, I; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Carballo, F
Published in: Transplantation
November 27, 1998

BACKGROUND: We report an investigation of the effects of cyclosporine (CsA) on kidney function, the glomerular synthesis of reactive oxygen species, the peroxidation of lipids, and the levels of thromboxane B2 (TXB2). The effect of the simultaneous administration of the antioxidant vitamin E (Vit E) and CsA in rats was also evaluated. METHODS: Adult male Wistar rats were treated for 30 days with CsA (30 mg/kg/day), with Vit E (0.05 mg/ml), with CsA plus Vit E, or with the vehicle used for administration of CsA, namely 12.6% ethanol. RESULTS: CsA induced kidney failure and increased the glomerular synthesis of superoxide anion, H2O2, malonyldialdehyde, and TXB2. Vit E minimized the adverse effects of CsA on kidney function and the glomerular synthesis of these compounds. CONCLUSIONS: Our results suggest that the acute decrease in glomerular filtration rate induced by CsA might be mediated by the synthesis of reactive oxygen species and subsequent peroxidation of lipids, which increases the levels of TXB2. Treatment with Vit E prevented these effects, suggesting a possible role for antioxidants in the prevention of CsA nephrotoxicity.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

November 27, 1998

Volume

66

Issue

10

Start / End Page

1325 / 1329

Location

United States

Related Subject Headings

  • Vitamin E
  • Surgery
  • Reactive Oxygen Species
  • Rats, Wistar
  • Rats
  • Malondialdehyde
  • Male
  • Lipid Peroxidation
  • Kidney Glomerulus
  • Kidney Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Parra, T., de Arriba, G., Conejo, J. R., Cantero, M., Arribas, I., Rodríguez-Puyol, D., … Carballo, F. (1998). Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity. Transplantation, 66(10), 1325–1329. https://doi.org/10.1097/00007890-199811270-00011
Parra, T., G. de Arriba, J. R. Conejo, M. Cantero, I. Arribas, D. Rodríguez-Puyol, M. Rodríguez-Puyol, and F. Carballo. “Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity.Transplantation 66, no. 10 (November 27, 1998): 1325–29. https://doi.org/10.1097/00007890-199811270-00011.
Parra T, de Arriba G, Conejo JR, Cantero M, Arribas I, Rodríguez-Puyol D, et al. Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity. Transplantation. 1998 Nov 27;66(10):1325–9.
Parra, T., et al. “Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity.Transplantation, vol. 66, no. 10, Nov. 1998, pp. 1325–29. Pubmed, doi:10.1097/00007890-199811270-00011.
Parra T, de Arriba G, Conejo JR, Cantero M, Arribas I, Rodríguez-Puyol D, Rodríguez-Puyol M, Carballo F. Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats: effect of vitamin E on cyclosporine nephrotoxicity. Transplantation. 1998 Nov 27;66(10):1325–1329.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

November 27, 1998

Volume

66

Issue

10

Start / End Page

1325 / 1329

Location

United States

Related Subject Headings

  • Vitamin E
  • Surgery
  • Reactive Oxygen Species
  • Rats, Wistar
  • Rats
  • Malondialdehyde
  • Male
  • Lipid Peroxidation
  • Kidney Glomerulus
  • Kidney Diseases