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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

Publication ,  Journal Article
Curiel, TJ; Coukos, G; Zou, L; Alvarez, X; Cheng, P; Mottram, P; Evdemon-Hogan, M; Conejo-Garcia, JR; Zhang, L; Burow, M; Zhu, Y; Wei, S ...
Published in: Nat Med
September 2004

Regulatory T (T(reg)) cells mediate homeostatic peripheral tolerance by suppressing autoreactive T cells. Failure of host antitumor immunity may be caused by exaggerated suppression of tumor-associated antigen-reactive lymphocytes mediated by T(reg) cells; however, definitive evidence that T(reg) cells have an immunopathological role in human cancer is lacking. Here we show, in detailed studies of CD4(+)CD25(+)FOXP3(+) T(reg) cells in 104 individuals affected with ovarian carcinoma, that human tumor T(reg) cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo. We also show that tumor T(reg) cells are associated with a high death hazard and reduced survival. Human T(reg) cells preferentially move to and accumulate in tumors and ascites, but rarely enter draining lymph nodes in later cancer stages. Tumor cells and microenvironmental macrophages produce the chemokine CCL22, which mediates trafficking of T(reg) cells to the tumor. This specific recruitment of T(reg) cells represents a mechanism by which tumors may foster immune privilege. Thus, blocking T(reg) cell migration or function may help to defeat human cancer.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 2004

Volume

10

Issue

9

Start / End Page

942 / 949

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Interleukin-2
  • Ovarian Neoplasms
  • Microscopy, Confocal
  • Mice
  • Lymphocyte Activation
  • Immunophenotyping
  • Immunology
  • Immunity, Cellular
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., … Zou, W. (2004). Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med, 10(9), 942–949. https://doi.org/10.1038/nm1093
Curiel, Tyler J., George Coukos, Linhua Zou, Xavier Alvarez, Pui Cheng, Peter Mottram, Melina Evdemon-Hogan, et al. “Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.Nat Med 10, no. 9 (September 2004): 942–49. https://doi.org/10.1038/nm1093.
Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004 Sep;10(9):942–9.
Curiel, Tyler J., et al. “Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.Nat Med, vol. 10, no. 9, Sept. 2004, pp. 942–49. Pubmed, doi:10.1038/nm1093.
Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, Zhu Y, Wei S, Kryczek I, Daniel B, Gordon A, Myers L, Lackner A, Disis ML, Knutson KL, Chen L, Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004 Sep;10(9):942–949.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 2004

Volume

10

Issue

9

Start / End Page

942 / 949

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Receptors, Interleukin-2
  • Ovarian Neoplasms
  • Microscopy, Confocal
  • Mice
  • Lymphocyte Activation
  • Immunophenotyping
  • Immunology
  • Immunity, Cellular
  • Humans