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Kidney-Function Trajectories From Young Adulthood to Midlife: Identifying Risk Strata and Opportunities for Intervention.

Publication ,  Journal Article
Guiney, H; Walker, R; Broadbent, J; Caspi, A; Goodin, E; Kokaua, J; Moffitt, TE; Robertson, S; Theodore, R; Poulton, R; Endre, Z
Published in: Kidney international reports
January 2023

Understanding normative patterns of change in kidney function over the life course may allow targeting of early interventions to slow or prevent the onset of kidney disease, but knowledge about kidney functional change before middle age is limited. This study used prospective longitudinal data from a representative birth cohort to examine common patterns of change from young to midadulthood and to identify risk factors and outcomes associated with poorer trajectories.We used group-based trajectory modeling in the Dunedin study birth cohort (n = 857) to identify the following: (i) common kidney function trajectories between the ages 32 and 45 years, (ii) early-life factors associated with those trajectories, (iii) modifiable physical and psychosocial factors across adulthood associated with differences in trajectory slope, and (iv) links between trajectories and kidney-related outcomes at age 45 years.Three trajectory groups were identified and could be differentiated by age 32 years as follows: normal (58% of participants), low-normal (36%), and high-risk (6%) groups. Those from low socioeconomic backgrounds had higher odds of following a high-risk (vs. normal) trajectory. Modifiable factors (blood pressure, body mass index, inflammation, glycated hemoglobin, smoking, and socioeconomic status) across adulthood were associated with steeper age-related declines in kidney function, particularly among those in the low-normal and high-risk groups. Those in the low-normal and high-risk groups also had more adverse kidney-related outcomes at age 45 years.The current findings could be used to inform the development of early interventions and point to socioeconomic conditions across the life course and health-related risk factors and behaviors in adulthood as kidney health promotion targets.

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Published In

Kidney international reports

DOI

EISSN

2468-0249

ISSN

2468-0249

Publication Date

January 2023

Volume

8

Issue

1

Start / End Page

51 / 63

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

APA
Chicago
ICMJE
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Guiney, H., Walker, R., Broadbent, J., Caspi, A., Goodin, E., Kokaua, J., … Endre, Z. (2023). Kidney-Function Trajectories From Young Adulthood to Midlife: Identifying Risk Strata and Opportunities for Intervention. Kidney International Reports, 8(1), 51–63. https://doi.org/10.1016/j.ekir.2022.10.005
Guiney, Hayley, Robert Walker, Jonathan Broadbent, Avshalom Caspi, Elizabeth Goodin, Jesse Kokaua, Terrie E. Moffitt, et al. “Kidney-Function Trajectories From Young Adulthood to Midlife: Identifying Risk Strata and Opportunities for Intervention.Kidney International Reports 8, no. 1 (January 2023): 51–63. https://doi.org/10.1016/j.ekir.2022.10.005.
Guiney H, Walker R, Broadbent J, Caspi A, Goodin E, Kokaua J, et al. Kidney-Function Trajectories From Young Adulthood to Midlife: Identifying Risk Strata and Opportunities for Intervention. Kidney international reports. 2023 Jan;8(1):51–63.
Guiney, Hayley, et al. “Kidney-Function Trajectories From Young Adulthood to Midlife: Identifying Risk Strata and Opportunities for Intervention.Kidney International Reports, vol. 8, no. 1, Jan. 2023, pp. 51–63. Epmc, doi:10.1016/j.ekir.2022.10.005.
Guiney H, Walker R, Broadbent J, Caspi A, Goodin E, Kokaua J, Moffitt TE, Robertson S, Theodore R, Poulton R, Endre Z. Kidney-Function Trajectories From Young Adulthood to Midlife: Identifying Risk Strata and Opportunities for Intervention. Kidney international reports. 2023 Jan;8(1):51–63.
Journal cover image

Published In

Kidney international reports

DOI

EISSN

2468-0249

ISSN

2468-0249

Publication Date

January 2023

Volume

8

Issue

1

Start / End Page

51 / 63

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences