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Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS).

Publication ,  Journal Article
Lin, EY-H; Xi, W; Aggarwal, N; Shinohara, ML
Published in: Int Immunol
April 4, 2023

Osteopontin (OPN) is a multifunctional protein, initially identified in osteosarcoma cells with its role of mediating osteoblast adhesion. Later studies revealed that OPN is associated with many inflammatory conditions caused by infections, allergic responses, autoimmunity and tissue damage. Many cell types in the peripheral immune system express OPN with various functions, which could be beneficial or detrimental. Also, more recent studies demonstrated that OPN is highly expressed in the central nervous system (CNS), particularly in microglia during CNS diseases and development. However, understanding of mechanisms underlying OPN's functions in the CNS is still limited. In this review, we focus on peripheral myeloid cells and CNS-resident cells to discuss the expression and functions of OPN.

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Published In

Int Immunol

DOI

EISSN

1460-2377

Publication Date

April 4, 2023

Volume

35

Issue

4

Start / End Page

171 / 180

Location

England

Related Subject Headings

  • Osteopontin
  • Microglia
  • Immunology
  • Immune System
  • Central Nervous System
  • Autoimmunity
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Lin, E.-H., Xi, W., Aggarwal, N., & Shinohara, M. L. (2023). Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS). Int Immunol, 35(4), 171–180. https://doi.org/10.1093/intimm/dxac060
Lin, Elliot Yi-Hsin, Wen Xi, Nupur Aggarwal, and Mari L. Shinohara. “Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS).Int Immunol 35, no. 4 (April 4, 2023): 171–80. https://doi.org/10.1093/intimm/dxac060.
Lin, Elliot Yi-Hsin, et al. “Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS).Int Immunol, vol. 35, no. 4, Apr. 2023, pp. 171–80. Pubmed, doi:10.1093/intimm/dxac060.
Journal cover image

Published In

Int Immunol

DOI

EISSN

1460-2377

Publication Date

April 4, 2023

Volume

35

Issue

4

Start / End Page

171 / 180

Location

England

Related Subject Headings

  • Osteopontin
  • Microglia
  • Immunology
  • Immune System
  • Central Nervous System
  • Autoimmunity
  • 3204 Immunology
  • 1107 Immunology