Abstract IA011: Coordinated T and B cell responses exert immune pressure against malignant progression
Conejo-Garcia, JR
Published in: Clinical Cancer Research
Memory B-cell and plasma cell infiltrates have been associated with better outcome in ovarian cancer, but the nature and functional relevance of these responses in other gynecologic malignancies remains elusive. Using a cohort totaling 107 endometrial cancers of different histological subtypes we show that the density of T cell infiltrates is associated with improved outcome in low-grade endometrial cancer, while better survival is associated with increased B cell and plasma cell infiltrates in high-grade endometrioid tumors. IgA and IgG are similarly abundant in endometrial tumors, but play opposite roles, whereby IgA:tumor cell co-localization is associated with accelerated malignant progression in clear cell and high-grade endometrioid tumors, while binding of IgG is associated with improved outcome in the same histological subtypes. Our data indicate that T cell and B cell responses work in coordination against endometrial cancer, but their role in tumor progression depends on the flavor of these responses and the histological subtype of endometrial cancer.Citation Format: Jose R. Conejo-Garcia. Coordinated T and B cell responses exert immune pressure against malignant progression [abstract]. In: Proceedings of the AACR Virtual Special Conference: Endometrial Cancer: New Biology Driving Research and Treatment; 2020 Nov 9-10. Philadelphia (PA): AACR; Clin Cancer Res 2021;27(3_Suppl):Abstract nr IA011.
