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Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.

Publication ,  Journal Article
Mohan, H; An, X; Xu, XH; Kondo, H; Zhao, S; Matho, KS; Wang, B-S; Musall, S; Mitra, P; Huang, ZJ
Published in: Nat Neurosci
March 2023

The cellular basis of cerebral cortex functional architecture remains not well understood. A major challenge is to monitor and decipher neural network dynamics across broad cortical areas yet with projection-neuron-type resolution in real time during behavior. Combining genetic targeting and wide-field imaging, we monitored activity dynamics of subcortical-projecting (PTFezf2) and intratelencephalic-projecting (ITPlxnD1) types across dorsal cortex of mice during different brain states and behaviors. ITPlxnD1 and PTFezf2 neurons showed distinct activation patterns during wakeful resting, during spontaneous movements and upon sensory stimulation. Distinct ITPlxnD1 and PTFezf2 subnetworks were dynamically tuned to different sensorimotor components of a naturalistic feeding behavior, and optogenetic inhibition of ITsPlxnD1 and PTsFezf2 in subnetwork nodes disrupted distinct components of this behavior. Lastly, ITPlxnD1 and PTFezf2 projection patterns are consistent with their subnetwork activation patterns. Our results show that, in addition to the concept of columnar organization, dynamic areal and projection-neuron-type specific subnetworks are a key feature of cortical functional architecture linking microcircuit components with global brain networks.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

March 2023

Volume

26

Issue

3

Start / End Page

481 / 494

Location

United States

Related Subject Headings

  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Membrane Glycoproteins
  • Intracellular Signaling Peptides and Proteins
  • Interneurons
  • Cerebral Cortex
  • Brain
  • Animals
  • 5202 Biological psychology
 

Citation

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Mohan, H., An, X., Xu, X. H., Kondo, H., Zhao, S., Matho, K. S., … Huang, Z. J. (2023). Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks. Nat Neurosci, 26(3), 481–494. https://doi.org/10.1038/s41593-022-01244-w
Mohan, Hemanth, Xu An, X Hermione Xu, Hideki Kondo, Shengli Zhao, Katherine S. Matho, Bor-Shuen Wang, Simon Musall, Partha Mitra, and Z Josh Huang. “Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.Nat Neurosci 26, no. 3 (March 2023): 481–94. https://doi.org/10.1038/s41593-022-01244-w.
Mohan H, An X, Xu XH, Kondo H, Zhao S, Matho KS, et al. Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks. Nat Neurosci. 2023 Mar;26(3):481–94.
Mohan, Hemanth, et al. “Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.Nat Neurosci, vol. 26, no. 3, Mar. 2023, pp. 481–94. Pubmed, doi:10.1038/s41593-022-01244-w.
Mohan H, An X, Xu XH, Kondo H, Zhao S, Matho KS, Wang B-S, Musall S, Mitra P, Huang ZJ. Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks. Nat Neurosci. 2023 Mar;26(3):481–494.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

March 2023

Volume

26

Issue

3

Start / End Page

481 / 494

Location

United States

Related Subject Headings

  • Neurons
  • Neurology & Neurosurgery
  • Mice
  • Membrane Glycoproteins
  • Intracellular Signaling Peptides and Proteins
  • Interneurons
  • Cerebral Cortex
  • Brain
  • Animals
  • 5202 Biological psychology