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Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.

Publication ,  Journal Article
Fu, Z; Brooks, MM; Irvin, S; Jordan, S; Aben, KKH; Anton-Culver, H; Bandera, EV; Beckmann, MW; Berchuck, A; Brooks-Wilson, A; Chang-Claude, J ...
Published in: Journal of the National Cancer Institute
May 2023

The role of ovulation in epithelial ovarian cancer (EOC) is supported by the consistent protective effects of parity and oral contraceptive use. Whether these factors protect through anovulation alone remains unclear. We explored the association between lifetime ovulatory years (LOY) and EOC.LOY was calculated using 12 algorithms. Odds ratios (ORs) and 95% confidence intervals (CIs) estimated the association between LOY or LOY components and EOC among 26 204 control participants and 21 267 case patients from 25 studies. To assess whether LOY components act through ovulation suppression alone, we compared beta coefficients obtained from regression models with expected estimates assuming 1 year of ovulation suppression has the same effect regardless of source.LOY was associated with increased EOC risk (OR per year increase = 1.014, 95% CI = 1.009 to 1.020 to OR per year increase = 1.044, 95% CI = 1.041 to 1.048). Individual LOY components, except age at menarche, also associated with EOC. The estimated model coefficient for oral contraceptive use and pregnancies were 4.45 times and 12- to 15-fold greater than expected, respectively. LOY was associated with high-grade serous, low-grade serous, endometrioid, and clear cell histotypes (ORs per year increase = 1.054, 1.040, 1.065, and 1.098, respectively) but not mucinous tumors. Estimated coefficients of LOY components were close to expected estimates for high-grade serous but larger than expected for low-grade serous, endometrioid, and clear cell histotypes.LOY is positively associated with nonmucinous EOC. Differences between estimated and expected model coefficients for LOY components suggest factors beyond ovulation underlie the associations between LOY components and EOC in general and for non-HGSOC.

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Published In

Journal of the National Cancer Institute

DOI

EISSN

1460-2105

ISSN

0027-8874

Publication Date

May 2023

Volume

115

Issue

5

Start / End Page

539 / 551

Related Subject Headings

  • Risk Factors
  • Pregnancy
  • Parity
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Contraceptives, Oral
  • Case-Control Studies
  • Carcinoma, Ovarian Epithelial
 

Citation

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Fu, Z., Brooks, M. M., Irvin, S., Jordan, S., Aben, K. K. H., Anton-Culver, H., … Modugno, F. (2023). Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis. Journal of the National Cancer Institute, 115(5), 539–551. https://doi.org/10.1093/jnci/djad011
Fu, Zhuxuan, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa V. Bandera, et al. “Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.Journal of the National Cancer Institute 115, no. 5 (May 2023): 539–51. https://doi.org/10.1093/jnci/djad011.
Fu Z, Brooks MM, Irvin S, Jordan S, Aben KKH, Anton-Culver H, et al. Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis. Journal of the National Cancer Institute. 2023 May;115(5):539–51.
Fu, Zhuxuan, et al. “Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis.Journal of the National Cancer Institute, vol. 115, no. 5, May 2023, pp. 539–51. Epmc, doi:10.1093/jnci/djad011.
Fu Z, Brooks MM, Irvin S, Jordan S, Aben KKH, Anton-Culver H, Bandera EV, Beckmann MW, Berchuck A, Brooks-Wilson A, Chang-Claude J, Cook LS, Cramer DW, Cushing-Haugen KL, Doherty JA, Ekici AB, Fasching PA, Fortner RT, Gayther SA, Gentry-Maharaj A, Giles GG, Goode EL, Goodman MT, Harris HR, Hein A, Kaaks R, Kiemeney LA, Köbel M, Kotsopoulos J, Le ND, Lee AW, Matsuo K, McGuire V, McLaughlin JR, Menon U, Milne RL, Moysich KB, Pearce CL, Pike MC, Qin B, Ramus SJ, Riggan MJ, Rothstein JH, Schildkraut JM, Sieh W, Sutphen R, Terry KL, Thompson PJ, Titus L, van Altena AM, White E, Whittemore AS, Wu AH, Zheng W, Ziogas A, Taylor SE, Tang L, Songer T, Wentzensen N, Webb PM, AOCS Group, Risch HA, Modugno F. Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis. Journal of the National Cancer Institute. 2023 May;115(5):539–551.
Journal cover image

Published In

Journal of the National Cancer Institute

DOI

EISSN

1460-2105

ISSN

0027-8874

Publication Date

May 2023

Volume

115

Issue

5

Start / End Page

539 / 551

Related Subject Headings

  • Risk Factors
  • Pregnancy
  • Parity
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Contraceptives, Oral
  • Case-Control Studies
  • Carcinoma, Ovarian Epithelial