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A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients.

Publication ,  Journal Article
Watson, CH; Spinosa, D; Hayes, T; Scott, A; Jackson, L; Thacker, JK; Sherman, KL; Moss, HA; Havrilesky, LJ; McNally, JL
Published in: Journal of lower genital tract disease
April 2023

Human papillomavirus (HPV)-related squamous intraepithelial lesion (SIL) or malignancy is associated with a significantly increased risk of second-site SIL or malignancy. The primary objective of this study was to determine the feasibility and acceptability of concurrent anal, cervical, and vulvovaginal screening in patients with a history of HPV-related gynecologic high-grade SIL or malignancy. The secondary objective was to assess subjects' knowledge regarding HPV screening and risks.Women with high-grade cervical, vulvar, or vaginal SIL or malignancy were enrolled during a 1-year pilot period. Subjects with cervical SIL or malignancy underwent vulvar examination and anoscopy. Subjects with vulvovaginal SIL or malignancy underwent Pap test if indicated and anoscopy. Appropriate referrals were made for abnormal findings. Feasibility was assessed by compliance using study acceptance rate, screening procedure adherence, and referral adherence. Acceptability was assessed using a Likert-scaled question after completion of screening procedures.One hundred three women with a diagnosis of high-grade vulvovaginal or cervical SIL or carcinoma were approached regarding study enrollment; of these, 74 (71.8%) enrolled. The median score on the HPV knowledge assessment was 8.1 ± 1.6 (max score 10). Seventy-three (98.6%) of 74 patients rated the screening procedures as acceptable (score of 5/5). On examination, 14 (18.9%) subjects had abnormalities noted; 7 (9.5%) were referred for colorectal surgical evaluation, and 6/7 (85.7%) were compliant with their referral appointments.Screening examinations for other HPV-related SILs and malignancies, including Pap tests, vulvovaginal inspection, and anoscopy, are acceptable to patients, with abnormal findings in almost 1 in 5 women.

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Published In

Journal of lower genital tract disease

DOI

EISSN

1526-0976

ISSN

1089-2591

Publication Date

April 2023

Volume

27

Issue

2

Start / End Page

120 / 124

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Squamous Intraepithelial Lesions
  • Pilot Projects
  • Papillomavirus Infections
  • Papillomaviridae
  • Obstetrics & Reproductive Medicine
  • Humans
  • Human Papillomavirus Viruses
 

Citation

APA
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ICMJE
MLA
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Watson, C. H., Spinosa, D., Hayes, T., Scott, A., Jackson, L., Thacker, J. K., … McNally, J. L. (2023). A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients. Journal of Lower Genital Tract Disease, 27(2), 120–124. https://doi.org/10.1097/lgt.0000000000000723
Watson, Catherine H., Daniel Spinosa, Taylor Hayes, Amelia Scott, Louise Jackson, Julie K. Thacker, Karen L. Sherman, Haley A. Moss, Laura J. Havrilesky, and J Leah McNally. “A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients.Journal of Lower Genital Tract Disease 27, no. 2 (April 2023): 120–24. https://doi.org/10.1097/lgt.0000000000000723.
Watson CH, Spinosa D, Hayes T, Scott A, Jackson L, Thacker JK, et al. A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients. Journal of lower genital tract disease. 2023 Apr;27(2):120–4.
Watson, Catherine H., et al. “A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients.Journal of Lower Genital Tract Disease, vol. 27, no. 2, Apr. 2023, pp. 120–24. Epmc, doi:10.1097/lgt.0000000000000723.
Watson CH, Spinosa D, Hayes T, Scott A, Jackson L, Thacker JK, Sherman KL, Moss HA, Havrilesky LJ, McNally JL. A Pilot Study of a Screening Program for Human Papillomavirus-Related Squamous Intraepithelial Lesion and Malignancy in Gynecologic Oncology Patients. Journal of lower genital tract disease. 2023 Apr;27(2):120–124.

Published In

Journal of lower genital tract disease

DOI

EISSN

1526-0976

ISSN

1089-2591

Publication Date

April 2023

Volume

27

Issue

2

Start / End Page

120 / 124

Related Subject Headings

  • Vaginal Smears
  • Uterine Cervical Neoplasms
  • Uterine Cervical Dysplasia
  • Squamous Intraepithelial Lesions
  • Pilot Projects
  • Papillomavirus Infections
  • Papillomaviridae
  • Obstetrics & Reproductive Medicine
  • Humans
  • Human Papillomavirus Viruses