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Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study.

Publication ,  Journal Article
Wang, L; Smith-Salzberg, B; Meyers, KE; Glenn, DA; Tuttle, KR; Derebail, VK; Brady, TM; Gibson, K; Smith, AR; O'Shaughnessy, MM; Srivastava, T ...
Published in: BMC Nephrol
February 9, 2023

BACKGROUND: Tobacco exposure has been recognized as a risk factor for cardiovascular disease (CVD) and progression of kidney disease. Patients with proteinuric glomerulopathies are at increased risk for cardiovascular morbidity and mortality. Multiple studies have linked tobacco exposure to CVD and chronic kidney disease, but the relationships between smoking and proteinuric glomerulopathies in adults and children have not been previously explored. METHODS: Data from the Nephrotic Syndrome Study Network (NEPTUNE), a multi-center prospective observational study of participants with proteinuric glomerulopathies, was analyzed. 371 adults and 192 children enrolled in NEPTUNE were included in the analysis. Self-reported tobacco exposure was classified as non-smoker, active smoker, former smoker, or exclusive passive smoker. Baseline serum cotinine levels were measured in a sub-cohort of 178 participants. RESULTS: The prevalence of active smokers, former smokers and exclusive passive smoking among adults at baseline was 14.6%, 29.1% and 4.9%, respectively. Passive smoke exposure was 16.7% among children. Active smoking (reference non-smoking) was significantly associated with greater total cholesterol among adults (β 17.91 95% CI 0.06, 35.76, p = 0.049) while passive smoking (reference non-smoking) was significantly associated with greater proteinuria over time among children (β 1.23 95% CI 0.13, 2.33, p = 0.03). Higher cotinine levels were associated with higher baseline eGFR (r = 0.17, p = 0.03). CONCLUSION: Tobacco exposure is associated with greater risk for CVD and worse kidney disease outcomes in adults and children with proteinuric glomerulopathies. Preventive strategies to reduce tobacco exposure may help protect against future cardiovascular and kidney morbidity and mortality in patients with proteinuric glomerulopathies.

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Published In

BMC Nephrol

DOI

EISSN

1471-2369

Publication Date

February 9, 2023

Volume

24

Issue

1

Start / End Page

30

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Tobacco Smoke Pollution
  • Nicotiana
  • Neptune
  • Kidney Diseases
  • Humans
  • Cotinine
  • Cohort Studies
  • Child
  • Cardiovascular Diseases
 

Citation

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ICMJE
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Wang, L., Smith-Salzberg, B., Meyers, K. E., Glenn, D. A., Tuttle, K. R., Derebail, V. K., … Sethna, C. B. (2023). Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study. BMC Nephrol, 24(1), 30. https://doi.org/10.1186/s12882-023-03073-w
Wang, Linda, Bayle Smith-Salzberg, Kevin Ec Meyers, Dorey A. Glenn, Katherine R. Tuttle, Vimal K. Derebail, Tammy M. Brady, et al. “Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study.BMC Nephrol 24, no. 1 (February 9, 2023): 30. https://doi.org/10.1186/s12882-023-03073-w.
Wang L, Smith-Salzberg B, Meyers KE, Glenn DA, Tuttle KR, Derebail VK, et al. Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study. BMC Nephrol. 2023 Feb 9;24(1):30.
Wang, Linda, et al. “Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study.BMC Nephrol, vol. 24, no. 1, Feb. 2023, p. 30. Pubmed, doi:10.1186/s12882-023-03073-w.
Wang L, Smith-Salzberg B, Meyers KE, Glenn DA, Tuttle KR, Derebail VK, Brady TM, Gibson K, Smith AR, O’Shaughnessy MM, Srivastava T, Hall G, Zee J, Bitzer M, Sethna CB. Tobacco exposure in adults and children with proteinuric glomerulopathies: a NEPTUNE cohort study. BMC Nephrol. 2023 Feb 9;24(1):30.
Journal cover image

Published In

BMC Nephrol

DOI

EISSN

1471-2369

Publication Date

February 9, 2023

Volume

24

Issue

1

Start / End Page

30

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Tobacco Smoke Pollution
  • Nicotiana
  • Neptune
  • Kidney Diseases
  • Humans
  • Cotinine
  • Cohort Studies
  • Child
  • Cardiovascular Diseases