Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel

Moonlighting chromatin: when DNA escapes nuclear control.

Publication ,  Journal Article
Singh, J; Boettcher, M; Dölling, M; Heuer, A; Hohberger, B; Leppkes, M; Naschberger, E; Schapher, M; Schauer, C; Schoen, J; Stürzl, M; Wang, H ...
Published in: Cell Death and Differentiation
April 2023

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an important element that propels the pathological progression of a plethora of diseases. DNA drives the interferon system, serves as autoantigen, and forms the extracellular scaffold for proteins of the innate immune system. An insufficient clearance of extruded chromatin after the release of DNA from the nucleus into the extracellular milieu can perform a secret task of moonlighting in immune-inflammatory and occlusive disorders. Here, we discuss (I) the cellular events involved in the extracellular release of chromatin and NET formation, (II) the devastating consequence of a dysregulated NET formation, and (III) the imbalance between NET formation and clearance. We include the role of NET formation in the occlusion of vessels and ducts, in lung disease, in autoimmune diseases, in chronic oral disorders, in cancer, in the formation of adhesions, and in traumatic spinal cord injury. To develop effective therapies, it is of utmost importance to target pathways that cause decondensation of chromatin during exaggerated NET formation and aggregation. Alternatively, therapies that support the clearance of extracellular chromatin are conceivable.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Death and Differentiation

DOI

EISSN

1476-5403

ISSN

1350-9047

Publication Date

April 2023

Volume

30

Issue

4

Start / End Page

861 / 875

Related Subject Headings

  • Neutrophils
  • Humans
  • Extracellular Traps
  • DNA
  • Chronic Disease
  • Chromatin
  • Biochemistry & Molecular Biology
  • Autoimmune Diseases
  • 11 Medical and Health Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Singh, J., Boettcher, M., Dölling, M., Heuer, A., Hohberger, B., Leppkes, M., … Knopf, J. (2023). Moonlighting chromatin: when DNA escapes nuclear control. Cell Death and Differentiation, 30(4), 861–875. https://doi.org/10.1038/s41418-023-01124-1
Singh, Jeeshan, Michael Boettcher, Maximilian Dölling, Annika Heuer, Bettina Hohberger, Moritz Leppkes, Elisabeth Naschberger, et al. “Moonlighting chromatin: when DNA escapes nuclear control.Cell Death and Differentiation 30, no. 4 (April 2023): 861–75. https://doi.org/10.1038/s41418-023-01124-1.
Singh J, Boettcher M, Dölling M, Heuer A, Hohberger B, Leppkes M, et al. Moonlighting chromatin: when DNA escapes nuclear control. Cell Death and Differentiation. 2023 Apr;30(4):861–75.
Singh, Jeeshan, et al. “Moonlighting chromatin: when DNA escapes nuclear control.Cell Death and Differentiation, vol. 30, no. 4, Apr. 2023, pp. 861–75. Epmc, doi:10.1038/s41418-023-01124-1.
Singh J, Boettcher M, Dölling M, Heuer A, Hohberger B, Leppkes M, Naschberger E, Schapher M, Schauer C, Schoen J, Stürzl M, Vitkov L, Wang H, Zlatar L, Schett GA, Pisetsky DS, Liu M-L, Herrmann M, Knopf J. Moonlighting chromatin: when DNA escapes nuclear control. Cell Death and Differentiation. 2023 Apr;30(4):861–875.

Published In

Cell Death and Differentiation

DOI

EISSN

1476-5403

ISSN

1350-9047

Publication Date

April 2023

Volume

30

Issue

4

Start / End Page

861 / 875

Related Subject Headings

  • Neutrophils
  • Humans
  • Extracellular Traps
  • DNA
  • Chronic Disease
  • Chromatin
  • Biochemistry & Molecular Biology
  • Autoimmune Diseases
  • 11 Medical and Health Sciences
  • 06 Biological Sciences