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The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study.

Publication ,  Journal Article
Karanth, SD; Akinyemiju, T; Walker, CJ; Yang, D; Migliorati, CA; Yoon, H-S; Hong, Y-R; Washington, CJ; Lattimore, C; Fredenburg, KM; Braithwaite, D
Published in: Cancer Epidemiol Biomarkers Prev
April 3, 2023

BACKGROUND: Head and neck cancer (HNC) mortality differs by race, ethnicity, and socioeconomic status (SES). However, it is unclear whether the relationship between race/ethnicity and HNC-specific mortality varies according to the residence-level SES. METHODS: Data from the Surveillance Epidemiology and End Results database included participants with primary HNC between 2006 and 2017 (followed through 2018) to assess the joint association of race/ethnicity and census-tract level SES Yost-index groups (quintiles) with all-cause and HNC-specific mortalities. Relative survival rates at 1, 5, and 10 years were calculated. Multivariable Cox proportional hazard regression models estimated hazard-ratios and 95% confidence intervals for all-cause mortality, and Fine-Gray subdistribution hazard models for HNC-specific mortality. Cumulative incidence curves for HNC-specific deaths were estimated. RESULTS: 76,095 patients were included in the analysis: 63.2% were <65 years, 73.4% male, and 11.3% non-Hispanic (NH) Black. Most patients (58.3%) were diagnosed at regional or distant stages and 20.6% died of HNC. The five-year relative survival rate increased with SES group, with 51.6% in the lowest SES group, and 74.1% in the highest SES group. NH-Black patients had higher risk of all-cause and HNC-specific mortality than NH-White patients, regardless of the SES group. NH-Asian/Pacific Islander and Hispanic patients had higher risk of HNC-specific mortality in some SES groups. CONCLUSIONS: NH-Black patients of all SES strata had significantly worse outcomes. Other factors, such as healthcare quality, may be associated with persistent disparities. IMPACT: The study highlights the persistence of significant racial disparities in HNC survival across socioeconomic categories. There is need to consider additional factors underlying these disparities.

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Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 3, 2023

Volume

32

Issue

4

Start / End Page

516 / 523

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Social Class
  • SEER Program
  • Racial Groups
  • Male
  • Intersectional Framework
  • Humans
  • Health Status Disparities
  • Head and Neck Neoplasms
  • Female
 

Citation

APA
Chicago
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MLA
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Karanth, S. D., Akinyemiju, T., Walker, C. J., Yang, D., Migliorati, C. A., Yoon, H.-S., … Braithwaite, D. (2023). The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study. Cancer Epidemiol Biomarkers Prev, 32(4), 516–523. https://doi.org/10.1158/1055-9965.EPI-22-1167
Karanth, Shama D., Tomi Akinyemiju, Courtney J. Walker, Danting Yang, Cesar A. Migliorati, Hyung-Suk Yoon, Young-Rock Hong, et al. “The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study.Cancer Epidemiol Biomarkers Prev 32, no. 4 (April 3, 2023): 516–23. https://doi.org/10.1158/1055-9965.EPI-22-1167.
Karanth SD, Akinyemiju T, Walker CJ, Yang D, Migliorati CA, Yoon H-S, et al. The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study. Cancer Epidemiol Biomarkers Prev. 2023 Apr 3;32(4):516–23.
Karanth, Shama D., et al. “The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study.Cancer Epidemiol Biomarkers Prev, vol. 32, no. 4, Apr. 2023, pp. 516–23. Pubmed, doi:10.1158/1055-9965.EPI-22-1167.
Karanth SD, Akinyemiju T, Walker CJ, Yang D, Migliorati CA, Yoon H-S, Hong Y-R, Washington CJ, Lattimore C, Fredenburg KM, Braithwaite D. The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study. Cancer Epidemiol Biomarkers Prev. 2023 Apr 3;32(4):516–523.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 3, 2023

Volume

32

Issue

4

Start / End Page

516 / 523

Location

United States

Related Subject Headings

  • Socioeconomic Factors
  • Social Class
  • SEER Program
  • Racial Groups
  • Male
  • Intersectional Framework
  • Humans
  • Health Status Disparities
  • Head and Neck Neoplasms
  • Female