Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.
Publication
, Journal Article
Tuyishime, M; Lawrence, R; Cocklin, S
Published in: Bioorg Med Chem Lett
January 1, 2016
Demand remains for new inhibitors of HIV-1 replication and the inhibition of HIV-1 entry is an extremely attractive therapeutic approach. Using field-based bioisosteric replacements, we have further extended the chemotypes available for development in the HIV-1 entry inhibitor class. Moreover, using field-based disparity analysis of the compounds, 3D structure-activity relationships were derived that will be useful in the further development of these inhibitors towards clinical utility.
Duke Scholars
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
January 1, 2016
Volume
26
Issue
1
Start / End Page
228 / 234
Location
England
Related Subject Headings
- Virus Internalization
- Structure-Activity Relationship
- Static Electricity
- Molecular Structure
- Models, Molecular
- Medicinal & Biomolecular Chemistry
- Hydrophobic and Hydrophilic Interactions
- HIV-1
- Anti-HIV Agents
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Tuyishime, M., Lawrence, R., & Cocklin, S. (2016). Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement. Bioorg Med Chem Lett, 26(1), 228–234. https://doi.org/10.1016/j.bmcl.2015.10.080
Tuyishime, Marina, Rae Lawrence, and Simon Cocklin. “Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.” Bioorg Med Chem Lett 26, no. 1 (January 1, 2016): 228–34. https://doi.org/10.1016/j.bmcl.2015.10.080.
Tuyishime M, Lawrence R, Cocklin S. Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement. Bioorg Med Chem Lett. 2016 Jan 1;26(1):228–34.
Tuyishime, Marina, et al. “Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement.” Bioorg Med Chem Lett, vol. 26, no. 1, Jan. 2016, pp. 228–34. Pubmed, doi:10.1016/j.bmcl.2015.10.080.
Tuyishime M, Lawrence R, Cocklin S. Core chemotype diversification in the HIV-1 entry inhibitor class using field-based bioisosteric replacement. Bioorg Med Chem Lett. 2016 Jan 1;26(1):228–234.
Published In
Bioorg Med Chem Lett
DOI
EISSN
1464-3405
Publication Date
January 1, 2016
Volume
26
Issue
1
Start / End Page
228 / 234
Location
England
Related Subject Headings
- Virus Internalization
- Structure-Activity Relationship
- Static Electricity
- Molecular Structure
- Models, Molecular
- Medicinal & Biomolecular Chemistry
- Hydrophobic and Hydrophilic Interactions
- HIV-1
- Anti-HIV Agents
- 1115 Pharmacology and Pharmaceutical Sciences