Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.
Publication
, Journal Article
Wong, HR; Walley, KR; Pettilä, V; Meyer, NJ; Russell, JA; Karlsson, S; Shashaty, MGS; Lindsell, CJ
Published in: Biomarkers
March 2015
CONTEXT: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. OBJECTIVE: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). METHODS: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). RESULTS: The area under the curve for ASSIST was greater than that of IL6 and PCT. CONCLUSIONS: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.
Duke Scholars
Published In
Biomarkers
DOI
EISSN
1366-5804
Publication Date
March 2015
Volume
20
Issue
2
Start / End Page
132 / 135
Location
England
Related Subject Headings
- Toxicology
- Survival Rate
- Survival Analysis
- Shock, Septic
- Severity of Illness Index
- Sepsis
- Risk Factors
- Risk Assessment
- Reproducibility of Results
- ROC Curve
Citation
APA
Chicago
ICMJE
MLA
NLM
Wong, H. R., Walley, K. R., Pettilä, V., Meyer, N. J., Russell, J. A., Karlsson, S., … Lindsell, C. J. (2015). Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers, 20(2), 132–135. https://doi.org/10.3109/1354750X.2014.1000971
Published In
Biomarkers
DOI
EISSN
1366-5804
Publication Date
March 2015
Volume
20
Issue
2
Start / End Page
132 / 135
Location
England
Related Subject Headings
- Toxicology
- Survival Rate
- Survival Analysis
- Shock, Septic
- Severity of Illness Index
- Sepsis
- Risk Factors
- Risk Assessment
- Reproducibility of Results
- ROC Curve