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Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.

Publication ,  Journal Article
Wong, HR; Walley, KR; Pettilä, V; Meyer, NJ; Russell, JA; Karlsson, S; Shashaty, MGS; Lindsell, CJ
Published in: Biomarkers
March 2015

CONTEXT: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk. OBJECTIVE: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT). METHODS: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235). RESULTS: The area under the curve for ASSIST was greater than that of IL6 and PCT. CONCLUSIONS: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

Duke Scholars

Published In

Biomarkers

DOI

EISSN

1366-5804

Publication Date

March 2015

Volume

20

Issue

2

Start / End Page

132 / 135

Location

England

Related Subject Headings

  • Toxicology
  • Survival Rate
  • Survival Analysis
  • Shock, Septic
  • Severity of Illness Index
  • Sepsis
  • Risk Factors
  • Risk Assessment
  • Reproducibility of Results
  • ROC Curve
 

Citation

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Chicago
ICMJE
MLA
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Wong, H. R., Walley, K. R., Pettilä, V., Meyer, N. J., Russell, J. A., Karlsson, S., … Lindsell, C. J. (2015). Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers, 20(2), 132–135. https://doi.org/10.3109/1354750X.2014.1000971
Wong, Hector R., Keith R. Walley, Ville Pettilä, Nuala J. Meyer, James A. Russell, Sari Karlsson, Michael G. S. Shashaty, and Christopher J. Lindsell. “Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.Biomarkers 20, no. 2 (March 2015): 132–35. https://doi.org/10.3109/1354750X.2014.1000971.
Wong HR, Walley KR, Pettilä V, Meyer NJ, Russell JA, Karlsson S, et al. Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers. 2015 Mar;20(2):132–5.
Wong, Hector R., et al. “Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.Biomarkers, vol. 20, no. 2, Mar. 2015, pp. 132–35. Pubmed, doi:10.3109/1354750X.2014.1000971.
Wong HR, Walley KR, Pettilä V, Meyer NJ, Russell JA, Karlsson S, Shashaty MGS, Lindsell CJ. Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock. Biomarkers. 2015 Mar;20(2):132–135.

Published In

Biomarkers

DOI

EISSN

1366-5804

Publication Date

March 2015

Volume

20

Issue

2

Start / End Page

132 / 135

Location

England

Related Subject Headings

  • Toxicology
  • Survival Rate
  • Survival Analysis
  • Shock, Septic
  • Severity of Illness Index
  • Sepsis
  • Risk Factors
  • Risk Assessment
  • Reproducibility of Results
  • ROC Curve