Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.
Publication
, Journal Article
Li, H; Saucedo-Cuevas, L; Yuan, L; Ross, D; Johansen, A; Sands, D; Stanley, V; Guemez-Gamboa, A; Gregor, A; Evans, T; Chen, S; Tan, L; Xu, Z ...
Published in: Neuron
March 20, 2019
Zika virus (ZIKV) targets neural progenitor cells in the brain, attenuates cell proliferation, and leads to cell death. Here, we describe a role for the ZIKV protease NS2B-NS3 heterodimer in mediating neurotoxicity through cleavage of a host protein required for neurogenesis. Similar to ZIKV infection, NS2B-NS3 expression led to cytokinesis defects and cell death in a protease activity-dependent fashion. Among binding partners, NS2B-NS3 cleaved Septin-2, a cytoskeletal factor involved in cytokinesis. Cleavage of Septin-2 occurred at residue 306 and forced expression of a non-cleavable Septin-2 restored cytokinesis, suggesting a direct mechanism of ZIKV-induced neural toxicity. VIDEO ABSTRACT.
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Published In
Neuron
DOI
EISSN
1097-4199
Publication Date
March 20, 2019
Volume
101
Issue
6
Start / End Page
1089 / 1098.e4
Location
United States
Related Subject Headings
- Zika Virus
- Viral Nonstructural Proteins
- Serine Endopeptidases
- Septins
- RNA Helicases
- Neurology & Neurosurgery
- Neurogenesis
- Neural Stem Cells
- Mitosis
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, H., Saucedo-Cuevas, L., Yuan, L., Ross, D., Johansen, A., Sands, D., … Gleeson, J. G. (2019). Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron, 101(6), 1089-1098.e4. https://doi.org/10.1016/j.neuron.2019.01.010
Li, Hongda, Laura Saucedo-Cuevas, Ling Yuan, Danica Ross, Anide Johansen, Daniel Sands, Valentina Stanley, et al. “Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.” Neuron 101, no. 6 (March 20, 2019): 1089-1098.e4. https://doi.org/10.1016/j.neuron.2019.01.010.
Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, et al. Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 2019 Mar 20;101(6):1089-1098.e4.
Li, Hongda, et al. “Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.” Neuron, vol. 101, no. 6, Mar. 2019, pp. 1089-1098.e4. Pubmed, doi:10.1016/j.neuron.2019.01.010.
Li H, Saucedo-Cuevas L, Yuan L, Ross D, Johansen A, Sands D, Stanley V, Guemez-Gamboa A, Gregor A, Evans T, Chen S, Tan L, Molina H, Sheets N, Shiryaev SA, Terskikh AV, Gladfelter AS, Shresta S, Xu Z, Gleeson JG. Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 2019 Mar 20;101(6):1089-1098.e4.
Published In
Neuron
DOI
EISSN
1097-4199
Publication Date
March 20, 2019
Volume
101
Issue
6
Start / End Page
1089 / 1098.e4
Location
United States
Related Subject Headings
- Zika Virus
- Viral Nonstructural Proteins
- Serine Endopeptidases
- Septins
- RNA Helicases
- Neurology & Neurosurgery
- Neurogenesis
- Neural Stem Cells
- Mitosis
- Humans